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    Usp12 ubiquitin specific peptidase 12 [ Mus musculus (house mouse) ]

    Gene ID: 22217, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp12provided by MGI
    Official Full Name
    ubiquitin specific peptidase 12provided by MGI
    Primary source
    MGI:MGI:1270128
    See related
    Ensembl:ENSMUSG00000029640 AllianceGenome:MGI:1270128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubh1
    Summary
    Enables deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; gonad; metanephros; and retina layer. Orthologous to human USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.4), large intestine adult (RPKM 10.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Usp12 in Genome Data Viewer
    Location:
    5 G3; 5 86.0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146671619..146731817, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146734809..146794956, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930573C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E11308 Neighboring gene predicted gene, 34700 Neighboring gene STARR-seq mESC enhancer starr_14850 Neighboring gene STARR-positive B cell enhancer ABC_E6401 Neighboring gene RIKEN cDNA 1700041I07 gene Neighboring gene STARR-seq mESC enhancer starr_14852 Neighboring gene STARR-positive B cell enhancer ABC_E6402 Neighboring gene STARR-positive B cell enhancer ABC_E6403 Neighboring gene predicted gene, 25091 Neighboring gene ribosomal protein L21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 12
    Names
    deubiquitinating enzyme 12
    ubiquitin specific protease 12
    ubiquitin thioesterase 12
    ubiquitin thiolesterase 12
    ubiquitin-hydrolyzing enzyme 1
    ubiquitin-specific-processing protease 12
    NP_035799.1
    XP_006504882.1
    XP_030110225.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011669.3NP_035799.1  ubiquitin carboxyl-terminal hydrolase 12

      See identical proteins and their annotated locations for NP_035799.1

      Status: PROVISIONAL

      Source sequence(s)
      AC124828, AC127589
      Consensus CDS
      CCDS39395.1
      UniProtKB/Swiss-Prot
      Q790B0, Q7TNV4, Q80Y43, Q8CBN8, Q9D9M2
      Related
      ENSMUSP00000082754.6, ENSMUST00000085614.6
      Conserved Domains (2) summary
      cd02663
      Location:40367
      Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:38366
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      146671619..146731817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254365.2XP_030110225.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X1

      Related
      ENSMUST00000138202.8
      Conserved Domains (1) summary
      cd02663
      Location:1247
      Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    2. XM_006504819.4XP_006504882.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X2

      Conserved Domains (1) summary
      cl02553
      Location:40194
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...