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    Gja10 gap junction protein, alpha 10 [ Mus musculus (house mouse) ]

    Gene ID: 14610, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gja10provided by MGI
    Official Full Name
    gap junction protein, alpha 10provided by MGI
    Primary source
    MGI:MGI:1339969
    See related
    Ensembl:ENSMUSG00000051056 AllianceGenome:MGI:1339969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cx59; Cxnn; cx57; Cx-57
    Summary
    Enables gap junction channel activity. Acts upstream of or within detection of light stimulus involved in visual perception; gamete generation; and synapse assembly. Located in gap junction. Is expressed in several structures, including eye; gonad; intestine; liver; and sciatic nerve. Orthologous to human GJA10 (gap junction protein alpha 10). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gja10 in Genome Data Viewer
    Location:
    4 A5; 4 14.25 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32594595..32607382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32600865..32602382, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4615 Neighboring gene STARR-positive B cell enhancer ABC_E7959 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32345161-32345344 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon CCC) Neighboring gene BTB and CNC homology, basic leucine zipper transcription factor 2 Neighboring gene VISTA enhancer mm720 Neighboring gene STARR-positive B cell enhancer ABC_E7960 Neighboring gene STARR-positive B cell enhancer ABC_E11713 Neighboring gene STARR-positive B cell enhancer ABC_E6157 Neighboring gene STARR-positive B cell enhancer ABC_E1639 Neighboring gene STARR-positive B cell enhancer mm9_chr4:32478184-32478485 Neighboring gene STARR-seq mESC enhancer starr_09864 Neighboring gene VISTA enhancer mm510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32647355-32647538 Neighboring gene STARR-seq mESC enhancer starr_09865 Neighboring gene STARR-positive B cell enhancer ABC_E6158 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene caspase 8 associated protein 2 Neighboring gene midasin AAA ATPase 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gamete generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of connexin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gap junction alpha-10 protein
    Names
    connexin n
    connexin-57
    gap junction membrane channel protein alpha 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411853.1NP_001398782.1  gap junction alpha-10 protein

      Status: VALIDATED

      Source sequence(s)
      AL831746
      UniProtKB/Swiss-Prot
      A2ANV0, Q9WUS4
      UniProtKB/TrEMBL
      A0A654ICX6
      Related
      ENSMUSP00000151323.2, ENSMUST00000219644.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32594595..32607382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010289.2: Suppressed sequence

      Description
      NM_010289.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.