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    Defb3 defensin beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 27358, updated on 9-Dec-2024

    Summary

    Official Symbol
    Defb3provided by MGI
    Official Full Name
    defensin beta 3provided by MGI
    Primary source
    MGI:MGI:1351612
    See related
    Ensembl:ENSMUSG00000039775 AllianceGenome:MGI:1351612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BD-3
    Summary
    Predicted to enable CCR6 chemokine receptor binding activity; chemoattractant activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in skin. Orthologous to human DEFB4A (defensin beta 4A) and DEFB4B (defensin beta 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Defb3 in Genome Data Viewer
    Location:
    8 A1.3; 8 10.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19343377..19345355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19293361..19295339)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin beta 46 Neighboring gene defensin beta 5 Neighboring gene defensin, alpha, pseudogene 13 Neighboring gene STARR-seq mESC enhancer starr_20863 Neighboring gene defensin, alpha, pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC129397

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR6 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013756.2NP_038784.1  beta-defensin 3 precursor

      See identical proteins and their annotated locations for NP_038784.1

      Status: VALIDATED

      Source sequence(s)
      AC113099, AF092929
      Consensus CDS
      CCDS40258.1
      UniProtKB/Swiss-Prot
      Q29R78, Q9WTL0
      Related
      ENSMUSP00000033852.8, ENSMUST00000033852.8
      Conserved Domains (1) summary
      pfam00711
      Location:2861
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      19343377..19345355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)