Slc26a2 solute carrier family 26 (sulfate transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc26a2provided by MGI
Official Full Name: solute carrier family 26 (sulfate transporter), member 2provided by MGI
Primary source: MGI:MGI:892977
See related: Ensembl:ENSMUSG00000034320 AllianceGenome:MGI:892977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dtd; ST-OB
Summary: Enables solute:inorganic anion antiporter activity and sulfate transmembrane transporter activity. Involved in chondrocyte differentiation; chondrocyte proliferation; and sulfate transmembrane transport. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study diastrophic dysplasia. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 28.9), large intestine adult (RPKM 11.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61329926..61344668, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (61196854..61211596, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

support a multifactorial etiology, involving congenitally predisposed isthmic conditions, altered biomechanics, and age-dependent bone loss, which leads to SLC26A2-related spondylolysis
Title: Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.
the present study has expanded our view of the sulfate transporter SLC26A2 to the unexpected field of collagen secretion and proteostasis. Our findings will facilitate the understanding of genotype-phenotype relationships of SLC26A2-related chondrodysplasias and accelerate the development of drug therapy against ACG1B and AO2.
Title: Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias.
Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion.
Title: Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion.
These findings reveal multiple roles for Slc26a2 in chondrocyte biology and emphasize the importance of Slc26a2-mediated protein sulfation in cell signaling
Title: Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions.
a Slc26a2 mutation results in matrix disruptions, growth, and degradation of cartilage with impaired sulfation
Title: Matrix disruptions, growth, and degradation of cartilage with impaired sulfation.
Characterize transport of oxalate and sulfate by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes.
Title: Regulated transport of sulfate and oxalate by SLC26A2/DTDST.
Homozygous mutant mice for SLC26A2 were characterized by skeletal dysplasia with chondrocytes of irregular size, delay in the formation of the secondary ossification centre and osteoporosis of long bones.
Title: Insights from a transgenic mouse model on the role of SLC26A2 in health and disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc26a2 (e-PCR), detects polymorphism
- UniSTS:142874

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sulfate transporter

Names: diastrophic dysplasia protein homolog; solute carrier family 26 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007885.2 → NP_031911.1 sulfate transporter

See identical proteins and their annotated locations for NP_031911.1

Status: VALIDATED

Source sequence(s)

AC148012, AK052942

Consensus CDS

CCDS29282.1

UniProtKB/Swiss-Prot

Q543D6, Q62273, Q8R2L9

Related

ENSMUSP00000119447.2, ENSMUST00000146409.8

Conserved Domains (2) summary

TIGR00815
Location:94 → 715

sulP; high affinity sulphate transporter 1

cl00604
Location:570 → 707

STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors