U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Bphl biphenyl hydrolase like [ Mus musculus (house mouse) ]

    Gene ID: 68021, updated on 3-Dec-2024

    Summary

    Official Symbol
    Bphlprovided by MGI
    Official Full Name
    biphenyl hydrolase likeprovided by MGI
    Primary source
    MGI:MGI:1915271
    See related
    Ensembl:ENSMUSG00000038286 AllianceGenome:MGI:1915271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable alpha-amino-acid esterase activity. Located in mitochondrion. Is expressed in atrioventricular canal; brain; nasal septum; trigeminal ganglion; and turbinate bone primordium. Orthologous to human BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 126.2), liver adult (RPKM 81.4) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bphl in Genome Data Viewer
    Location:
    13 A3.3; 13 14.02 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34221611..34258055)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34037585..34074074)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene N-ribosyldihydronicotinamide quinone reductase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2403 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene RIKEN cDNA 4930447K03 gene Neighboring gene tubulin, beta 2A class IIA Neighboring gene STARR-seq mESC enhancer starr_34135

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-amino-acid esterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-amino-acid esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    valacyclovir hydrolase
    Names
    VACVase
    biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
    biphenyl hydrolase-like protein
    valacyclovirase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418740.1NP_001405669.1  valacyclovir hydrolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161117
      UniProtKB/TrEMBL
      Q3TDN8
    2. NM_001418742.1NP_001405671.1  valacyclovir hydrolase isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161117
    3. NM_001418743.1NP_001405672.1  valacyclovir hydrolase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161117
    4. NM_001418744.1NP_001405673.1  valacyclovir hydrolase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161117
    5. NM_001418745.1NP_001405674.1  valacyclovir hydrolase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161117
    6. NM_001418748.1NP_001405677.1  valacyclovir hydrolase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161117
    7. NM_026512.2NP_080788.1  valacyclovir hydrolase isoform 1 precursor

      See identical proteins and their annotated locations for NP_080788.1

      Status: VALIDATED

      Source sequence(s)
      AC161117
      Consensus CDS
      CCDS49229.1
      UniProtKB/Swiss-Prot
      Q8BVH2, Q8R164, Q8R589, Q9DCC6
      UniProtKB/TrEMBL
      Q3TDN8
      Related
      ENSMUSP00000046168.7, ENSMUST00000040656.8
      Conserved Domains (2) summary
      COG0596
      Location:44291
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:58259
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34221611..34258055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)