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    Smcp sperm mitochondria-associated cysteine-rich protein [ Mus musculus (house mouse) ]

    Gene ID: 17235, updated on 9-Dec-2024

    Summary

    Official Symbol
    Smcpprovided by MGI
    Official Full Name
    sperm mitochondria-associated cysteine-rich proteinprovided by MGI
    Primary source
    MGI:MGI:96945
    See related
    Ensembl:ENSMUSG00000074435 AllianceGenome:MGI:96945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcs; Mcsp
    Summary
    Involved in flagellated sperm motility. Acts upstream of or within binding activity of sperm to zona pellucida and penetration of zona pellucida. Located in mitochondrion. Is expressed in testis. Orthologous to human SMCP (sperm mitochondria associated cysteine rich protein). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: There was a controversy about whether this gene encoded a selenoprotein, named mitochondrial capsule selenoprotein. A later study showed that not to be true and renamed it, sperm mitochondria-associated cysteine-rich protein (PMID:8916043). [04 Aug 2017]
    Expression
    Restricted expression toward testis adult (RPKM 1377.0) See more
    Orthologs
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    Genomic context

    See Smcp in Genome Data Viewer
    Location:
    3 F1; 3 40.14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (92491173..92496380, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (92583866..92589073, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small proline-rich protein 4 Neighboring gene predicted gene, 35639 Neighboring gene involucrin Neighboring gene late cornified envelope 6A Neighboring gene predicted gene, 35699

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General protein information

    Preferred Names
    sperm mitochondrial-associated cysteine-rich protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008574.4NP_032600.3  sperm mitochondrial-associated cysteine-rich protein

      Status: VALIDATED

      Source sequence(s)
      BC055104, BY066868, BY456161
      Consensus CDS
      CCDS89661.1
      UniProtKB/Swiss-Prot
      O70613, P15265, Q6P8N3
      Related
      ENSMUSP00000096487.6, ENSMUST00000098888.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      92491173..92496380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)