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    Ppp4r1 protein phosphatase 4, regulatory subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 70351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp4r1provided by MGI
    Official Full Name
    protein phosphatase 4, regulatory subunit 1provided by MGI
    Primary source
    MGI:MGI:1917601
    See related
    Ensembl:ENSMUSG00000061950 AllianceGenome:MGI:1917601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp4r1; 3110001J10Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be active in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP4R1 (protein phosphatase 4 regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 40.7), CNS E14 (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp4r1 in Genome Data Viewer
    Location:
    17 E1.1; 17 35.26 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66089253..66148921)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65782543..65841926)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene RAB31, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022 Neighboring gene STARR-seq mESC enhancer starr_43025 Neighboring gene STARR-seq mESC enhancer starr_43027 Neighboring gene ralA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10964 Neighboring gene predicted gene, 49870 Neighboring gene predicted gene, 35550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes. Wang S, et al. Mol Med Rep, 2018 Oct. PMID 30132533
    2. Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes. Hwang J, et al. J Biol Chem, 2016 Sep 30. PMID 27507813, Free PMC Article
    3. PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress. Zhu X, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37739270
    4. AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner. Xu W, et al. Cell Death Differ, 2024 May. PMID 38424148,
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
      Title: AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
    2. PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress.
      Title: PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress.
    3. miR3383p may be involved in TNFalphamediated gluconeogenesis via targeting of PP4R1 in hepatocytes.
      Title: miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes.
    4. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.
      Title: Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC31567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114131.1 → NP_001107603.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, CX568699
      Consensus CDS
      CCDS50167.1
      UniProtKB/TrEMBL
      E9PX53, Q3TLM9
      Related
      ENSMUSP00000124690.2, ENSMUST00000160664.8
      Conserved Domains (2) summary
      pfam15017
      Location:419 → 475
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:116 → 140
      HEAT; HEAT repeat [structural motif]

    2. NM_146081.2 → NP_666193.2  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, BY163631, CX568699
      Consensus CDS
      CCDS28941.2
      UniProtKB/Swiss-Prot
      Q8K2V1, Q8R0R8
      UniProtKB/TrEMBL
      E9QPR5
      Related
      ENSMUSP00000072848.5, ENSMUST00000073104.11
      Conserved Domains (2) summary
      pfam15017
      Location:436 → 492
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:133 → 157
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_104465.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC139751, AK133969, AK167713, BI135060
      Related
      ENSMUST00000162109.8

    2. NR_152099.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139751, BI135060, CT025659

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      66089253..66148921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524889.5 → XP_006524952.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524952.1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    2. XM_006524890.5 → XP_006524953.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524953.1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    3. XM_006524888.5 → XP_006524951.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524951.1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    4. XM_030250045.2 → XP_030105905.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    5. XM_030250046.2 → XP_030105906.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    6. XM_030250047.2 → XP_030105907.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3

      Conserved Domains (2) summary
      sd00044
      Location:316 → 344
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:105 → 123
      WRNPLPNID; Putative WW-binding domain and destruction box

    7. XM_006524891.5 → XP_006524954.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524954.1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    8. XM_006524892.5 → XP_006524955.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524955.1

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (2) summary
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:411 → 427
      WRNPLPNID; Putative WW-binding domain and destruction box

    9. XM_036160783.1 → XP_036016676.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

      UniProtKB/TrEMBL
      Q3TLM9
      Conserved Domains (3) summary
      sd00044
      Location:16 → 47
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:57 → 84
      HEAT; HEAT repeat
      pfam15017
      Location:258 → 292
      WRNPLPNID; Putative WW-binding domain and destruction box

    10. XM_006524895.5 → XP_006524958.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006524958.1

      UniProtKB/Swiss-Prot
      Q8K2V1
      Conserved Domains (2) summary
      sd00044
      Location:316 → 344
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:105 → 123
      WRNPLPNID; Putative WW-binding domain and destruction box

    RNA

    1. XR_003952177.1 RNA Sequence

    2. XR_001782110.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2V1.2 GenPept UniProtKB/Swiss-Prot:Q8K2V1

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