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    Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) [ Mus musculus (house mouse) ]

    Gene ID: 17133, updated on 3-Dec-2024

    Summary

    Official Symbol
    Maffprovided by MGI
    Official Full Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)provided by MGI
    Primary source
    MGI:MGI:96910
    See related
    Ensembl:ENSMUSG00000042622 AllianceGenome:MGI:96910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within in utero embryonic development; regulation of epidermal cell differentiation; and skeletal muscle cell differentiation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human MAFF (MAF bZIP transcription factor F). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in small intestine adult (RPKM 12.2), duodenum adult (RPKM 12.0) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Maff in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79230813..79243278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79346621..79359078)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VI Neighboring gene predicted gene, 41358 Neighboring gene STARR-positive B cell enhancer ABC_E7389 Neighboring gene predicted gene 20420 Neighboring gene STARR-positive B cell enhancer ABC_E1913 Neighboring gene STARR-seq mESC enhancer starr_39174 Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene STARR-seq mESC enhancer starr_39180 Neighboring gene STARR-seq mESC enhancer starr_39181 Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcription factor MafF
    Names
    V-maf musculoaponeurotic fibrosarcoma oncogene homolog F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304830.2NP_001291759.1  transcription factor MafF

      See identical proteins and their annotated locations for NP_001291759.1

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27638.1
      UniProtKB/Swiss-Prot
      O54791
      UniProtKB/TrEMBL
      Q3U0G5, Q3UKW6
      Related
      ENSMUSP00000154850.2, ENSMUST00000229130.2
      Conserved Domains (1) summary
      cd14717
      Location:47115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    2. NM_001304831.2NP_001291760.2  transcription factor MafF

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      O54791
      UniProtKB/TrEMBL
      Q3U0G5, Q3UKW6
      Related
      ENSMUSP00000131628.2, ENSMUST00000163691.3
    3. NM_001304832.3NP_001291761.2  transcription factor MafF

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      O54791
      UniProtKB/TrEMBL
      Q3U0G5, Q3UKW6
    4. NM_010755.5NP_034885.1  transcription factor MafF

      See identical proteins and their annotated locations for NP_034885.1

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27638.1
      UniProtKB/Swiss-Prot
      O54791
      UniProtKB/TrEMBL
      Q3U0G5, Q3UKW6
      Related
      ENSMUSP00000094076.4, ENSMUST00000096350.11
      Conserved Domains (1) summary
      cd14717
      Location:47115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79230813..79243278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159212.1XP_036015105.1  transcription factor MafF isoform X1

      Conserved Domains (1) summary
      cd14717
      Location:158226
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    2. XM_036159213.1XP_036015106.1  transcription factor MafF isoform X2

      UniProtKB/Swiss-Prot
      O54791
      UniProtKB/TrEMBL
      Q3U0G5, Q3UKW6
      Conserved Domains (1) summary
      cd14717
      Location:47115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    3. XM_006520550.5XP_006520613.1  transcription factor MafF isoform X2

      See identical proteins and their annotated locations for XP_006520613.1

      UniProtKB/Swiss-Prot
      O54791
      UniProtKB/TrEMBL
      Q3U0G5, Q3UKW6
      Conserved Domains (1) summary
      cd14717
      Location:47115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain