Trp63 transformation related protein 63 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trp63provided by MGI
Official Full Name: transformation related protein 63provided by MGI
Primary source: MGI:MGI:1330810
See related: Ensembl:ENSMUSG00000022510 AllianceGenome:MGI:1330810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ket; P63; P73l; Tp63; P51/P63; Trp53rp1
Summary: This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Expression: Biased expression in bladder adult (RPKM 13.9), genital fat pad adult (RPKM 5.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 17.37 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (25502513..25710842)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (25683763..25892088)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice.
Title: Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice.
DeltaNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis.
Title: ΔNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis.
Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-gamma signaling in squamous cancer.
Title: Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.
Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63.
Title: Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63.
Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.
Title: Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.
A TP63 mutation identified in a Han Chinese family with ectodermal dysplasia.
Title: A TP63 mutation identified in a Han Chinese family with ectodermal dysplasia.
TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.
Title: TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.
TAp63 determines the fate of oocytes against DNA damage.
Title: TAp63 determines the fate of oocytes against DNA damage.
DeltaNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland.
Title: ΔNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland.
The role of p63 in embryonic external genitalia outgrowth in mice.
Title: The role of p63 in embryonic external genitalia outgrowth in mice.

Submit: New GeneRIF Correction See all GeneRIFs (194)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (6)
Targeted (26) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trp63 (e-PCR), detects polymorphism
- UniSTS:257030

Trp63 (e-PCR), detects polymorphism
- UniSTS:144675

Trp63 (e-PCR), detects polymorphism
- UniSTS:144676

Trp63 (e-PCR), detects polymorphism
- UniSTS:144677

31.MMHAP58FLC4.seq (e-PCR)
- UniSTS:123947

AI462811 (e-PCR)
- UniSTS:180883

Trp63 (e-PCR), detects polymorphism
- UniSTS:499117

NoName (e-PCR)
- UniSTS:548555

NoName (e-PCR)
- UniSTS:548556

NoName (e-PCR)
- UniSTS:548557

NoName (e-PCR)
- UniSTS:548558

NoName (e-PCR)
- UniSTS:548559

Trp63 (e-PCR), detects polymorphism
- UniSTS:526811

Trp63 (e-PCR), detects polymorphism
- UniSTS:526812

Trp63 (e-PCR), detects polymorphism
- UniSTS:256989

Trp63 (e-PCR), detects polymorphism
- UniSTS:256990

AB010152 (e-PCR)
- UniSTS:163568

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables MDM2/MDM4 family protein binding	IEA Inferred from Electronic Annotation more info
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables WW domain binding	IEA Inferred from Electronic Annotation more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cloacal septation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectoderm and mesoderm interaction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermal cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of keratinocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polarized epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of keratinocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor protein 63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127259.1 → NP_001120731.1 tumor protein 63 isoform a

See identical proteins and their annotated locations for NP_001120731.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a, also known as TAp63alpha).

Source sequence(s)

AF075436, AK138305, BC090649

Consensus CDS

CCDS49809.1

UniProtKB/Swiss-Prot

O88897, O88898, O88899, O89097, Q8C826, Q9QWY9, Q9QWZ0

UniProtKB/TrEMBL

Q5CZX0

Related

ENSMUSP00000110965.3, ENSMUST00000115310.9

Conserved Domains (4) summary

cd09572
Location:543 → 607

SAM_tumor-p63; SAM domain of tumor-p63 proteins

pfam00870
Location:163 → 358

P53; P53 DNA-binding domain

pfam07710
Location:392 → 431

P53_tetramer; P53 tetramerisation motif

pfam08430
Location:452 → 535

Forkhead_N; Forkhead N-terminal region
NM_001127260.1 → NP_001120732.1 tumor protein 63 isoform b

See identical proteins and their annotated locations for NP_001120732.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (b, also known as TAp63beta) has a shorter and different C-terminus, as compared to isoform a.

Source sequence(s)

AF075435, AK138305, BC090649

Consensus CDS

CCDS49810.1

UniProtKB/Swiss-Prot

O88898

UniProtKB/TrEMBL

Q5CZX0

Related

ENSMUSP00000067005.6, ENSMUST00000065523.12

Conserved Domains (2) summary

cd08367
Location:177 → 358

P53; P53 DNA-binding domain

pfam07710
Location:392 → 428

P53_tetramer; P53 tetramerisation motif
NM_001127261.1 → NP_001120733.1 tumor protein 63 isoform c

See identical proteins and their annotated locations for NP_001120733.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal 12 nt segment and several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (c, also known as TAp63gamma) lacks internal 4 aa and has a shorter and different C-terminus, as compared to isoform a.

Source sequence(s)

AF075434, AK138305, AK140023, BC092537

Consensus CDS

CCDS49808.1

UniProtKB/Swiss-Prot

O88898

UniProtKB/TrEMBL

Q569E5

Related

ENSMUSP00000110963.3, ENSMUST00000115308.9

Conserved Domains (2) summary

cd08367
Location:177 → 358

P53; P53 DNA-binding domain

pfam07710
Location:388 → 424

P53_tetramer; P53 tetramerisation motif
NM_001127262.1 → NP_001120734.1 tumor protein 63 isoform f

See identical proteins and their annotated locations for NP_001120734.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) is an alternate promoter product; it lacks several 5' exons and an internal exon in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (f, also known as DNp63beta) has shorter and different N- and C-termini, as compared to isoform a.

Source sequence(s)

AF075438, AK048623, BC090649

UniProtKB/Swiss-Prot

O88898

UniProtKB/TrEMBL

Q5CZX0

Conserved Domains (2) summary

cd08367
Location:83 → 264

P53; P53 DNA-binding domain

pfam07710
Location:298 → 334

P53_tetramer; P53 tetramerisation motif
NM_001127263.1 → NP_001120735.1 tumor protein 63 isoform g

See identical proteins and their annotated locations for NP_001120735.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) is an alternate promoter product; it lacks several 5' and 3' exons, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (g, also known as DNp63gamma) has shorter and different N- and C-termini, as compared to isoform a.

Source sequence(s)

AK140023, BC092537

Consensus CDS

CCDS49812.1

UniProtKB/TrEMBL

Q569E5

Related

ENSMUSP00000110960.2, ENSMUST00000115305.2

Conserved Domains (2) summary

cd08367
Location:83 → 264

P53; P53 DNA-binding domain

pfam07710
Location:298 → 334

P53_tetramer; P53 tetramerisation motif
NM_001127264.1 → NP_001120736.1 tumor protein 63 isoform e

See identical proteins and their annotated locations for NP_001120736.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) is an alternate promoter product; it lacks several 5' exons and an internal 12 nt segment, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (e) has a shorter and different N-terminus, and lacks internal 4 aa, as compared to isoform a.

Source sequence(s)

AK048623, AK137253, BC090649

Consensus CDS

CCDS49811.1

UniProtKB/TrEMBL

Q3UVI3, Q5CZX0

Related

ENSMUSP00000110961.2, ENSMUST00000115306.8

Conserved Domains (3) summary

cd08367
Location:83 → 264

P53; P53 DNA-binding domain

cd09572
Location:445 → 509

SAM_tumor-p63; SAM domain of tumor-p63 proteins

pfam07710
Location:294 → 330

P53_tetramer; P53 tetramerisation motif
NM_001127265.1 → NP_001120737.1 tumor protein 63 isoform h

See identical proteins and their annotated locations for NP_001120737.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) is an alternate promoter product; it lacks several 5' and 3' exons and an internal 12 nt segment, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (h, also known as DNp63gamma) has shorter and different N- and C-termini, and lacks internal 4 aa, as compared to isoform a.

Source sequence(s)

AF075437, AK048623, AK140023, BC092537

UniProtKB/Swiss-Prot

O88898

UniProtKB/TrEMBL

Q569E5

Conserved Domains (2) summary

cd08367
Location:83 → 264

P53; P53 DNA-binding domain

pfam07710
Location:294 → 330

P53_tetramer; P53 tetramerisation motif
NM_001427037.1 → NP_001413966.1 tumor protein 63 isoform i

Status: REVIEWED

Source sequence(s)

AC109213, AC113020
NM_011641.2 → NP_035771.1 tumor protein 63 isoform d

See identical proteins and their annotated locations for NP_035771.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) is an alternate promoter product; it lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (d, also known as DNp63alpha) has a shorter and different N-terminus, as compared to isoform a.

Source sequence(s)

AF075439, AK048623, BC090649

Consensus CDS

CCDS28085.1

UniProtKB/TrEMBL

Q5CZX0

Related

ENSMUSP00000038117.7, ENSMUST00000040231.13

Conserved Domains (3) summary

cd08367
Location:83 → 264

P53; P53 DNA-binding domain

cd09572
Location:449 → 513

SAM_tumor-p63; SAM domain of tumor-p63 proteins

pfam07710
Location:298 → 334

P53_tetramer; P53 tetramerisation motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

25502513..25710842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522002.1 → XP_006522065.1 tumor protein 63 isoform X3

Conserved Domains (2) summary

cd08367
Location:177 → 358

P53; P53 DNA-binding domain

pfam07710
Location:392 → 428

P53_tetramer; P53 tetramerisation motif
XM_006522001.3 → XP_006522064.1 tumor protein 63 isoform X2

UniProtKB/TrEMBL

Q5CZX0

Conserved Domains (4) summary

cd08367
Location:58 → 239

P53; P53 DNA-binding domain

cd09572
Location:424 → 488

SAM_tumor-p63; SAM domain of tumor-p63 proteins

pfam07710
Location:273 → 309

P53_tetramer; P53 tetramerisation motif

pfam08430
Location:338 → 415

Forkhead_N; Forkhead N-terminal region