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    Ugt1a6a UDP glucuronosyltransferase 1 family, polypeptide A6A [ Mus musculus (house mouse) ]

    Gene ID: 94284, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt1a6aprovided by MGI
    Official Full Name
    UDP glucuronosyltransferase 1 family, polypeptide A6Aprovided by MGI
    Primary source
    MGI:MGI:2137698
    See related
    Ensembl:ENSMUSG00000054545 AllianceGenome:MGI:2137698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UDPGT; UGT1.6; Ugt1a6; Ugt1a7; UGT1-06; UDPGT 1-6
    Summary
    Enables alpha-glucuronidase activity and glucuronosyltransferase activity. Involved in L-ascorbic acid biosynthetic process. Acts upstream of or within glucuronate metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 228.4), liver adult (RPKM 161.8) and 13 other tissues See more
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    Genomic context

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    See Ugt1a6a in Genome Data Viewer
    Location:
    1 D; 1 44.52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88062531..88147724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88134809..88220002)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene predicted gene, 38421 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene STARR-seq mESC enhancer starr_01626 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene STARR-seq mESC enhancer starr_01627 Neighboring gene STARR-seq mESC enhancer starr_01628 Neighboring gene predicted gene 15372 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene 15371 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene predicted gene 15368 Neighboring gene predicted gene 15376 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells. Carmean CM, et al. Am J Physiol Endocrinol Metab, 2019 Mar 1. PMID 30562058, Free PMC Article
    2. Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain. Uchihashi S, et al. Drug Metab Pharmacokinet, 2013. PMID 23089803
    3. Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver. Linster CL, et al. FEBS J, 2006 Apr. PMID 16689937
    4. Cloning and characterization of a canine UDP-glucuronosyltransferase. Soars MG, et al. Arch Biochem Biophys, 2001 Jul 15. PMID 11437353
    5. Cotranscription of two RNA coding for the cell adhesion regulator and its variant in Reh leukemia cells. Molla A, et al. Biochim Biophys Acta, 1996 Jan 17. PMID 8611648

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study provides evidence that UGT1A6A, acting on the serotonin pathway, regulates glucose induced insulin secretion under both normal and pathological conditions.
      Title: Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells.
    2. the difference in expression levels between Ugt1a6a and Ugt1a6b in the hippocampus led us to speculate that Ugt1a6a is likely the predominant catalyst of serotonin glucuronidation in the mouse brain.
      Title: Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-glucuronidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-glucuronidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 4-chlorobiphenyl metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-ascorbic acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glucuronate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glucuronate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 1-6
    Names
    UDP glycosyltransferase 1 family, polypeptide A6
    UDP-glucuronosyltransferase 1A6
    phenol UDP-glucuronosyltransferase
    NP_659545.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145079.3 → NP_659545.2  UDP-glucuronosyltransferase 1-6 precursor

      See identical proteins and their annotated locations for NP_659545.2

      Status: VALIDATED

      Source sequence(s)
      AC087780, AC087801
      Consensus CDS
      CCDS48314.1
      UniProtKB/Swiss-Prot
      P70692, Q62580, Q64435, Q6XL47
      UniProtKB/TrEMBL
      Q6NSR5
      Related
      ENSMUSP00000108759.2, ENSMUST00000113134.8
      Conserved Domains (2) summary
      PHA03392
      Location:15 → 503
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:27 → 522
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88062531..88147724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64435.1 GenPept UniProtKB/Swiss-Prot:Q64435

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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