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    Nr4a2 nuclear receptor subfamily 4, group A, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 18227, updated on 17-Dec-2024

    Summary

    Official Symbol
    Nr4a2provided by MGI
    Official Full Name
    nuclear receptor subfamily 4, group A, member 2provided by MGI
    Primary source
    MGI:MGI:1352456
    See related
    Ensembl:ENSMUSG00000026826 AllianceGenome:MGI:1352456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NOT; HZF-3; Nurr1; RNR-1; TINOR; TINUR
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; dopaminergic neuron differentiation; and fat cell differentiation. Acts upstream of or within several processes, including dopamine biosynthetic process; general adaptation syndrome; and nervous system development. Located in nucleus. Is expressed in several structures, including ear; endocrine gland; genitourinary system; integumental system; and nervous system. Used to study Parkinson's disease and schizophrenia. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), stomach adult (RPKM 2.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Nr4a2 in Genome Data Viewer
    Location:
    2 C1.1; 2 31.66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (56996845..57014152, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (57106830..57124003, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33458 Neighboring gene microRNA 195b Neighboring gene STARR-seq mESC enhancer starr_04522 Neighboring gene STARR-seq mESC enhancer starr_04523 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_04524 Neighboring gene expressed sequence BB557941 Neighboring gene RIKEN cDNA 4930555B11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5916 Neighboring gene nuclear encoded tRNA alanine 8 (anticodon CGC)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables nuclear glucocorticoid receptor binding  
    enables nuclear glucocorticoid receptor binding PubMed 
    enables nuclear receptor activity PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables zinc ion binding  
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    involved_in DNA-templated transcription PubMed 
    involved_in DNA-templated transcription  
    acts_upstream_of_or_within adult locomotory behavior PubMed 
    involved_in cellular response to corticotropin-releasing hormone stimulus  
    involved_in cellular response to corticotropin-releasing hormone stimulus PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress PubMed 
    involved_in central nervous system neuron differentiation  
    acts_upstream_of_or_within central nervous system neuron differentiation PubMed 
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis PubMed 
    acts_upstream_of_or_within dopamine biosynthetic process PubMed 
    acts_upstream_of_or_within dopamine metabolic process PubMed 
    involved_in dopaminergic neuron differentiation  
    involved_in dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation PubMed 
    involved_in dopaminergic neuron differentiation PubMed 
    involved_in fat cell differentiation PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    acts_upstream_of_or_within general adaptation syndrome PubMed 
    acts_upstream_of_or_within habenula development PubMed 
    involved_in intracellular receptor signaling pathway  
    involved_in learning or memory  
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of apoptotic signaling pathway  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within nervous system development PubMed 
    acts_upstream_of neuron apoptotic process PubMed 
    acts_upstream_of_or_within neuron differentiation PubMed 
    acts_upstream_of_or_within neuron maturation PubMed 
    acts_upstream_of_or_within neuron migration PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of catalytic activity PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of dopamine metabolic process PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of respiratory gaseous exchange PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within response to amphetamine PubMed 
    acts_upstream_of_or_within response to hypoxia PubMed 
    acts_upstream_of_or_within response to insecticide PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    Items 1 - 25 of 49
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    nuclear receptor subfamily 4 group A member 2
    Names
    NUR-related factor 1
    nur related protein 1
    orphan nuclear receptor NURR1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139509.2NP_001132981.1  nuclear receptor subfamily 4 group A member 2 isoform a

      See identical proteins and their annotated locations for NP_001132981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1 and encodes isoform a. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL844871
      Consensus CDS
      CCDS16043.1
      UniProtKB/Swiss-Prot
      O08690, Q06219
      UniProtKB/TrEMBL
      Q3TYI4
      Related
      ENSMUSP00000108248.2, ENSMUST00000112629.8
      Conserved Domains (2) summary
      cd07071
      Location:361598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    2. NM_001420480.1NP_001407409.1  nuclear receptor subfamily 4 group A member 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL844871
      UniProtKB/Swiss-Prot
      O08690, Q06219
      UniProtKB/TrEMBL
      Q3TYI4
    3. NM_001420481.1NP_001407410.1  nuclear receptor subfamily 4 group A member 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL844871
      UniProtKB/TrEMBL
      A2AQQ8
    4. NM_001420482.1NP_001407411.1  nuclear receptor subfamily 4 group A member 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL844871
      UniProtKB/TrEMBL
      A2AQQ8
      Related
      ENSMUSP00000108246.2, ENSMUST00000112627.2
    5. NM_013613.3NP_038641.1  nuclear receptor subfamily 4 group A member 2 isoform a

      See identical proteins and their annotated locations for NP_038641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL844871
      Consensus CDS
      CCDS16043.1
      UniProtKB/Swiss-Prot
      O08690, Q06219
      UniProtKB/TrEMBL
      Q3TYI4
      Related
      ENSMUSP00000028166.3, ENSMUST00000028166.9
      Conserved Domains (2) summary
      cd07071
      Location:361598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RNA

    1. NR_185185.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844871
      Related
      ENSMUST00000183542.8
    2. NR_185186.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844871
    3. NR_185187.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844871

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      56996845..57014152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159386.1XP_036015279.1  nuclear receptor subfamily 4 group A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O08690, Q06219
      UniProtKB/TrEMBL
      Q3TYI4
      Conserved Domains (2) summary
      cd07071
      Location:361598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    2. XM_011239033.4XP_011237335.1  nuclear receptor subfamily 4 group A member 2 isoform X1

      See identical proteins and their annotated locations for XP_011237335.1

      UniProtKB/Swiss-Prot
      O08690, Q06219
      UniProtKB/TrEMBL
      Q3TYI4
      Conserved Domains (2) summary
      cd07071
      Location:361598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RNA

    1. XR_004938834.1 RNA Sequence

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