Mybpc2 myosin binding protein C, fast-type [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mybpc2provided by MGI
Official Full Name: myosin binding protein C, fast-typeprovided by MGI
Primary source: MGI:MGI:1336170
See related: Ensembl:ENSMUSG00000038670 AllianceGenome:MGI:1336170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in sarcomere organization. Predicted to act upstream of or within muscle contraction. Predicted to be located in cytoskeleton. Predicted to be active in M band. Is expressed in diaphragm; extensor digitorum longus; hindlimb; rectus femoris; and soleus. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 39.2) and heart adult (RPKM 2.0) See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.83 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44151123..44174093, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44501699..44524715, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.
Title: Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.
Fast and slow skeletal myosin binding protein-C and aging.
Title: Fast and slow skeletal myosin binding protein-C and aging.
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
Title: Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-binding protein C, fast-type

Names: fast MyBP-C; fast-type C-protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146189.3 → NP_666301.2 myosin-binding protein C, fast-type

See identical proteins and their annotated locations for NP_666301.2

Status: VALIDATED

Source sequence(s)

AK029282, AK132563, CK787764

Consensus CDS

CCDS52233.1

UniProtKB/Swiss-Prot

Q5XKE0, Q8C109, Q8K2V0

Related

ENSMUSP00000130127.3, ENSMUST00000165208.4

Conserved Domains (7) summary

cd00096
Location:1062 → 1127

Ig; Immunoglobulin domain

cd05748
Location:853 → 924

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd05894
Location:545 → 630

Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)

smart00410
Location:548 → 630

IG_like; Immunoglobulin like

cd00063
Location:634 → 720

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1043 → 1132

I-set; Immunoglobulin I-set domain

cl11960
Location:278 → 325

Ig; Immunoglobulin domain