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    Pcgf5 polycomb group ring finger 5 [ Mus musculus (house mouse) ]

    Gene ID: 76073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcgf5provided by MGI
    Official Full Name
    polycomb group ring finger 5provided by MGI
    Primary source
    MGI:MGI:1923505
    See related
    Ensembl:ENSMUSG00000024805 AllianceGenome:MGI:1923505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610009F02Rik; 1110054A01Rik; 5830406C17Rik; 5830443C21Rik; 9530023M17Rik
    Summary
    Enables histone H2AK119 ubiquitin ligase activity. Involved in random inactivation of X chromosome. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in bladder; central nervous system; embryo; heart; and ureter. Orthologous to human PCGF5 (polycomb group ring finger 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.9), heart adult (RPKM 3.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcgf5 in Genome Data Viewer
    Location:
    19 C2; 19 31.59 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36325729..36438370)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36348329..36460970)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32027 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:36316959-36317171 Neighboring gene predicted gene, 46664 Neighboring gene predicted gene, 57659 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:36459071-36459224 Neighboring gene IK cytokine pseudogene Neighboring gene STARR-seq mESC enhancer starr_46024 Neighboring gene STARR-seq mESC enhancer starr_46026 Neighboring gene predicted gene, 32143 Neighboring gene predicted gene, 41838

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells. Meng Y, et al. Dev Growth Differ, 2020 May. PMID 32130724
    2. PCGF5 is required for neural differentiation of embryonic stem cells. Yao M, et al. Nat Commun, 2018 May 15. PMID 29765032, Free PMC Article
    3. Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells. Zhao W, et al. J Biol Chem, 2017 Dec 29. PMID 29054931, Free PMC Article
    4. Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. Si S, et al. PLoS One, 2016. PMID 27136092, Free PMC Article
    5. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Fursova NA, et al. Mol Cell, 2019 Jun 6. PMID 31029541, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells.
      Title: Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells.
    2. the knockout of Pcgf3, Pcgf5, or both resulted in a 39, 29, and 52% decrease, respectively, in global levels of H2AK119ub1 as compared with wild-type cells, as evidenced by Western blotting. In contrast, no similar change was observed for H3K27me3.
      Title: Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells.
    3. Although PCGF5 is not required for embryonic stem cell (ESC) self-renewal, its loss blocks ESC neural differentiation by activating the SMAD2/TGF-beta signaling pathway.
      Title: PCGF5 is required for neural differentiation of embryonic stem cells.
    4. Authors conclude that RYBP/YAF2 binding to H2AK119u1 likely underpins the transient interaction of noncanonical PRC1 complexes with Xist RNA domains but does not account for stable interaction of PCGF3/5-PRC1 complexes.
      Title: PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
    5. hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing.
      Title: hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
    6. findings demonstrate that Pcgf5-containing PRC1 functions as a histone modifier in vivo, but its role in HSPCs is limited and can be compensated by other PRC1-related complexes in HSPCs.
      Title: Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AK119 ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in random inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with X chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 5
    Names
    RING finger protein 159

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368690.1 → NP_001355619.1  polycomb group RING finger protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117769
      Consensus CDS
      CCDS89384.1
      UniProtKB/Swiss-Prot
      B2RTD3, B7ZP23, Q3UK78, Q9D3E5, Q9DCW8
      UniProtKB/TrEMBL
      B7ZP24
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 256
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

    2. NM_001368691.1 → NP_001355620.1  polycomb group RING finger protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117769
      Consensus CDS
      CCDS89384.1
      UniProtKB/Swiss-Prot
      B2RTD3, B7ZP23, Q3UK78, Q9D3E5, Q9DCW8
      UniProtKB/TrEMBL
      B7ZP24
      Related
      ENSMUSP00000153464.2, ENSMUST00000225411.2
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 256
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

    3. NM_001368692.1 → NP_001355621.1  polycomb group RING finger protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA472895, AC117769, AK002387, AK004240, CX224153
      Consensus CDS
      CCDS29772.1
      UniProtKB/TrEMBL
      B7ZP24
      Related
      ENSMUSP00000153206.2, ENSMUST00000225920.2
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 236
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

    4. NM_001368693.1 → NP_001355622.1  polycomb group RING finger protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117769
      Consensus CDS
      CCDS29772.1
      UniProtKB/TrEMBL
      B7ZP24
      Related
      ENSMUSP00000058730.6, ENSMUST00000062389.6
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 236
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

    5. NM_029508.4 → NP_083784.1  polycomb group RING finger protein 5 isoform 2

      See identical proteins and their annotated locations for NP_083784.1

      Status: VALIDATED

      Source sequence(s)
      AC117769
      Consensus CDS
      CCDS29772.1
      UniProtKB/TrEMBL
      B7ZP24
      Related
      ENSMUSP00000071245.7, ENSMUST00000071267.14
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 236
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      36325729..36438370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161722.1 → XP_036017615.1  polycomb group RING finger protein 5 isoform X2

      UniProtKB/TrEMBL
      B7ZP24
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 236
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

    2. XM_011247392.4 → XP_011245694.1  polycomb group RING finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245694.1

      UniProtKB/Swiss-Prot
      B2RTD3, B7ZP23, Q3UK78, Q9D3E5, Q9DCW8
      UniProtKB/TrEMBL
      B7ZP24
      Conserved Domains (3) summary
      TIGR00599
      Location:8 → 135
      rad18; DNA repair protein rad18
      cd16737
      Location:16 → 57
      RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
      cd17084
      Location:136 → 256
      RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UK78.1 GenPept UniProtKB/Swiss-Prot:Q3UK78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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