Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdhcprovided by MGI
Official Full Name: succinate dehydrogenase complex, subunit C, integral membrane proteinprovided by MGI
Primary source: MGI:MGI:1913302
See related: Ensembl:ENSMUSG00000058076 AllianceGenome:MGI:1913302
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610010E03Rik
Summary: Predicted to enable heme binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 368.5), kidney adult (RPKM 283.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 78.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (170956726..170978209, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171129157..171150640, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
Title: SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
Studies indicate that the Tet-mev-1 conditional transgenic system can induce mutated SDHC gene in complex II.
Title: Model animals for the study of oxidative stress from complex II.
a sensor for apoptosis induction
Title: The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction.
complex II plays an essential role in hypoxic reactive oxygen species production.
Title: Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

24.MMHAP87FRH9.seq (e-PCR)
- UniSTS:123661

Sdhc (e-PCR), detects polymorphism
- UniSTS:507210

RH136553 (e-PCR)
- UniSTS:210535

AW742715 (e-PCR)
- UniSTS:207247

AI316496 (e-PCR)
- UniSTS:158883

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	NAS Non-traceable Author Statement more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Names: QPs-1; QPs1; integral membrane protein CII-3; malate dehydrogenase [quinone] cytochrome b560 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025321.3 → NP_079597.2 succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_079597.2

Status: VALIDATED

Source sequence(s)

AK002459, AV356234, BY711932

Consensus CDS

CCDS35772.1

UniProtKB/Swiss-Prot

Q544Q9, Q99JP2, Q9CZB0, Q9DCU7

UniProtKB/TrEMBL

Q5XK33

Related

ENSMUSP00000106968.4, ENSMUST00000111336.10

Conserved Domains (1) summary

cd03499
Location:50 → 152

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

170956726..170978209 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496955.3 → XP_006497018.2 succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1

UniProtKB/TrEMBL

Q5XK33

Conserved Domains (1) summary

cd03499
Location:31 → 133

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
XM_030241961.1 → XP_030097821.1 succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2

UniProtKB/TrEMBL

F8WGB3

Conserved Domains (1) summary

cd03499
Location:13 → 115

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...