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    Tmprss12 transmembrane (C-terminal) protease, serine 12 [ Mus musculus (house mouse) ]

    Gene ID: 75002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmprss12provided by MGI
    Official Full Name
    transmembrane (C-terminal) protease, serine 12provided by MGI
    Primary source
    MGI:MGI:1922252
    See related
    Ensembl:ENSMUSG00000045631 AllianceGenome:MGI:1922252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930478A21Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in acrosome assembly and positive regulation of sperm capacitation. Acts upstream of or within binding activity of sperm to zona pellucida and protein processing. Located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 14.1) See more
    Orthologs
    human all
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    Genomic context

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    See Tmprss12 in Genome Data Viewer
    Location:
    15 F1; 15 56.24 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100178743..100190943)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100280837..100293056)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:99890852-99891153 Neighboring gene disco interacting protein 2 homolog B Neighboring gene STARR-seq mESC enhancer starr_39737 Neighboring gene STARR-seq mESC enhancer starr_39738 Neighboring gene STARR-seq mESC enhancer starr_39739 Neighboring gene STARR-seq mESC enhancer starr_39742 Neighboring gene activating transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_39744 Neighboring gene STARR-seq mESC enhancer starr_39745 Neighboring gene STARR-seq mESC enhancer starr_39746 Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene STARR-positive B cell enhancer ABC_E9423 Neighboring gene predicted gene, 33666 Neighboring gene predicted gene, 53910 Neighboring gene thiol methyltransferase 1A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice. Zhang J, et al. Front Cell Dev Biol, 2022. PMID 35547804, Free PMC Article
    2. Tmprss12 is required for sperm motility and uterotubal junction migration in mice†. Larasati T, et al. Biol Reprod, 2020 Aug 4. PMID 32529245, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmprss12 is required for sperm motility and uterotubal junction migration in micedagger.
      Title: Tmprss12 is required for sperm motility and uterotubal junction migration in mice†.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418781.1 → NP_001405710.1  transmembrane protease serine 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124479

    2. NM_183109.4 → NP_898932.2  transmembrane protease serine 12 isoform 1 precursor

      See identical proteins and their annotated locations for NP_898932.2

      Status: VALIDATED

      Source sequence(s)
      AC124479
      Consensus CDS
      CCDS49732.1
      UniProtKB/Swiss-Prot
      Q3V0Q7
      Related
      ENSMUSP00000093914.5, ENSMUST00000096200.6
      Conserved Domains (2) summary
      smart00020
      Location:65 → 300
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:66 → 300
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100178743..100190943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0Q7.1 GenPept UniProtKB/Swiss-Prot:Q3V0Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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