Metap1d methionyl aminopeptidase type 1D (mitochondrial) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Metap1dprovided by MGI
Official Full Name: methionyl aminopeptidase type 1D (mitochondrial)provided by MGI
Primary source: MGI:MGI:1913809
See related: Ensembl:ENSMUSG00000041921 AllianceGenome:MGI:1913809
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Map1d; MAP 1D; Metapl1; MetAP 1D; 2310066F24Rik; 3110033D18Rik
Summary: Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Located in mitochondrion. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 8.6), CNS E14 (RPKM 7.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 42.42 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (71283625..71355538)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (71453281..71525194)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

RH143753 (e-PCR)
- UniSTS:232999

AV117938 (e-PCR)
- UniSTS:165173

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables initiator methionyl aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: methionine aminopeptidase 1D, mitochondrial

Names: metAP 1D; methionine aminopeptidase-like 1; peptidase M 1D

NP_001405450.1

EC 3.4.11.18

NP_001405451.1

EC 3.4.11.18

NP_001405452.1

EC 3.4.11.18

NP_001405453.1

EC 3.4.11.18

NP_001405454.1

EC 3.4.11.18

NP_001405455.1

EC 3.4.11.18

NP_079909.1

EC 3.4.11.18

XP_006500072.1

EC 3.4.11.18

XP_011238040.1

EC 3.4.11.18

XP_017174676.1

EC 3.4.11.18

XP_017174677.1

EC 3.4.11.18

XP_017174678.1

EC 3.4.11.18

XP_017174679.1

EC 3.4.11.18

XP_017174680.1

EC 3.4.11.18

XP_030107808.1

EC 3.4.11.18

XP_030107809.1

EC 3.4.11.18

XP_030107812.1

EC 3.4.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418521.1 → NP_001405450.1 methionine aminopeptidase 1D, mitochondrial isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL928931
NM_001418522.1 → NP_001405451.1 methionine aminopeptidase 1D, mitochondrial isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL928931
NM_001418523.1 → NP_001405452.1 methionine aminopeptidase 1D, mitochondrial isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL928931
NM_001418524.1 → NP_001405453.1 methionine aminopeptidase 1D, mitochondrial isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL928931

UniProtKB/TrEMBL

Q9CRV0
NM_001418525.1 → NP_001405454.1 methionine aminopeptidase 1D, mitochondrial isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AL928931

UniProtKB/TrEMBL

Q9CRV0
NM_001418526.1 → NP_001405455.1 methionine aminopeptidase 1D, mitochondrial isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AL928931

UniProtKB/TrEMBL

Q9CRV0
NM_025633.4 → NP_079909.1 methionine aminopeptidase 1D, mitochondrial isoform 3 precursor

See identical proteins and their annotated locations for NP_079909.1

Status: VALIDATED

Source sequence(s)

AL928931

Consensus CDS

CCDS16115.1

UniProtKB/Swiss-Prot

Q80WB3, Q91YD2, Q9CPW9

Related

ENSMUSP00000048190.9, ENSMUST00000037210.9

Conserved Domains (1) summary

cd01086
Location:94 → 330

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

RNA

NR_184762.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184763.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184764.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184765.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184766.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184767.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184768.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184769.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184770.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184771.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184772.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184773.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931
NR_184774.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928931

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

71283625..71355538

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319187.2 → XP_017174676.1 methionine aminopeptidase 1D, mitochondrial isoform X2

Conserved Domains (1) summary

cl00279
Location:94 → 336

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
XM_017319188.1 → XP_017174677.1 methionine aminopeptidase 1D, mitochondrial isoform X4

Conserved Domains (1) summary

cl00279
Location:94 → 234

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
XM_017319190.3 → XP_017174679.1 methionine aminopeptidase 1D, mitochondrial isoform X5

Conserved Domains (1) summary

cl00279
Location:94 → 239

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
XM_017319189.3 → XP_017174678.1 methionine aminopeptidase 1D, mitochondrial isoform X4

Conserved Domains (1) summary

cl00279
Location:94 → 234

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
XM_017319191.1 → XP_017174680.1 methionine aminopeptidase 1D, mitochondrial isoform X6

Conserved Domains (1) summary

cl00279
Location:94 → 237

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
XM_030251949.1 → XP_030107809.1 methionine aminopeptidase 1D, mitochondrial isoform X8

Conserved Domains (1) summary

cd01086
Location:1 → 280

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
XM_006500009.4 → XP_006500072.1 methionine aminopeptidase 1D, mitochondrial isoform X8

See identical proteins and their annotated locations for XP_006500072.1

Related

ENSMUST00000139045.8

Conserved Domains (1) summary

cd01086
Location:1 → 280

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
XM_030251948.1 → XP_030107808.1 methionine aminopeptidase 1D, mitochondrial isoform X8

Conserved Domains (1) summary

cd01086
Location:1 → 280

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
XM_030251952.2 → XP_030107812.1 methionine aminopeptidase 1D, mitochondrial isoform X9

Conserved Domains (1) summary

cd01086
Location:1 → 212

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
XM_011239738.4 → XP_011238040.1 methionine aminopeptidase 1D, mitochondrial isoform X3

Conserved Domains (1) summary

cd01086
Location:111 → 415

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.