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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001142706.2 → NP_001136178.1 complement factor B isoform 2 precursor
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
CT573030
- Consensus CDS
-
CCDS50079.1
- UniProtKB/TrEMBL
- B8JJM6, F6XQ00
- Related
- ENSMUSP00000120990.2, ENSMUST00000154526.8
- Conserved Domains (4) summary
-
- cd00033
Location:102 → 157
- CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
- smart00032
Location:54 → 82
- CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
- cd01470
Location:268 → 465
- vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
- cl21584
Location:488 → 599
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
-
NM_001402875.1 → NP_001389804.1 complement factor B isoform 3 precursor
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
CT573030
- UniProtKB/Swiss-Prot
-
P04186
- UniProtKB/TrEMBL
-
Q3UEG8
-
NM_008198.3 → NP_032224.2 complement factor B isoform 1 precursor
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
CT573030
- Consensus CDS
-
CCDS28663.2
- UniProtKB/Swiss-Prot
-
P04186
- UniProtKB/TrEMBL
- B8JJM5, Q3UEG8
- Related
- ENSMUSP00000025229.5, ENSMUST00000025229.11
- Conserved Domains (5) summary
-
- cd00033
Location:102 → 157
- CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
- smart00032
Location:54 → 82
- CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
- cd00190
Location:488 → 754
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- cd01470
Location:268 → 465
- vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
- pfam00089
Location:490 → 751
- Trypsin; Trypsin
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000083.7 Reference GRCm39 C57BL/6J
- Range
-
35075350..35081492 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006523672.3 → XP_006523735.1 complement factor B isoform X2
See identical proteins and their annotated locations for XP_006523735.1
- UniProtKB/TrEMBL
-
F6XQ00
- Conserved Domains (4) summary
-
- cd00033
Location:102 → 157
- CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
- smart00032
Location:54 → 82
- CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
- cd01470
Location:268 → 465
- vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
- cl21584
Location:488 → 599
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...