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    C4a complement C4A (Rodgers blood group) [ Mus musculus (house mouse) ]

    Gene ID: 625018, updated on 27-Nov-2024

    Summary

    Official Symbol
    C4aprovided by MGI
    Official Full Name
    complement C4A (Rodgers blood group)provided by MGI
    Primary source
    MGI:MGI:98320
    See related
    Ensembl:ENSMUSG00000015451 AllianceGenome:MGI:98320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C4; C4b; Slp; SlpA
    Summary
    Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to human C4A (complement C4A (Chido/Rodgers blood group)) and C4B (complement C4B (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Biased expression in liver adult (RPKM 55.0), subcutaneous fat pad adult (RPKM 18.7) and 10 other tissues See more
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    Genomic context

    See C4a in Genome Data Viewer
    Location:
    17 B1; 17 18.37 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35028069..35042436, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34809092..34823460, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1 Neighboring gene tenascin XA (pseudogene) Neighboring gene Cyp21a1 5' regulatory region Neighboring gene cytochrome P450, family 21, subfamily a, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_42439 Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E8920 Neighboring gene decapping exoribonuclease

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C1q complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within complement activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in symbiont cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sex-limited protein
    Names
    Complement C4-B
    complement component 4A (Rodgers blood group)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011413.2NP_035543.2  sex-limited protein precursor

      See identical proteins and their annotated locations for NP_035543.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein.
      Source sequence(s)
      AK129017, AW987669, M12384
      UniProtKB/TrEMBL
      V9GZQ6
      Conserved Domains (8) summary
      cd00017
      Location:684752
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:9891308
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      pfam00207
      Location:777864
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:139231
      A2M_N; MG2 domain
      pfam07677
      Location:14721561
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10441310
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:475608
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15791733
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    RNA

    1. NR_160726.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.
      Source sequence(s)
      CT573030
      Related
      ENSMUST00000160679.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35028069..35042436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)