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    Egfl8 EGF-like domain 8 [ Mus musculus (house mouse) ]

    Gene ID: 81701, updated on 3-Dec-2024

    Summary

    Official Symbol
    Egfl8provided by MGI
    Official Full Name
    EGF-like domain 8provided by MGI
    Primary source
    MGI:MGI:1932094
    See related
    Ensembl:ENSMUSG00000015467 AllianceGenome:MGI:1932094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ng3
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including diaphragm; genitourinary system; gut; hemolymphoid system gland; and trigeminal nerve. Orthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 162.7), small intestine adult (RPKM 77.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Egfl8 in Genome Data Viewer
    Location:
    17 B1; 17 18.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34832174..34835536, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34613349..34616562, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene STARR-positive B cell enhancer ABC_E45 Neighboring gene ring finger protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E11640 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene proline-rich transmembrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    NOT involved_in in utero embryonic development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in vasculogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    epidermal growth factor-like protein 8
    Names
    EGF-like protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403845.1NP_001390774.1  epidermal growth factor-like protein 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767
      UniProtKB/Swiss-Prot
      O35447, Q3UFB4, Q6GUQ1
      UniProtKB/TrEMBL
      B7ZP51, B9EJ41
    2. NM_152922.4NP_690886.3  epidermal growth factor-like protein 8 precursor

      See identical proteins and their annotated locations for NP_690886.3

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS28651.1
      UniProtKB/Swiss-Prot
      O35447, Q3UFB4, Q6GUQ1
      UniProtKB/TrEMBL
      B7ZP51, B9EJ41
      Related
      ENSMUSP00000015611.8, ENSMUST00000015611.14
      Conserved Domains (2) summary
      smart00179
      Location:144183
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:37101
      EMI; EMI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34832174..34835536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525180.5XP_006525243.1  epidermal growth factor-like protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006525243.1

      UniProtKB/TrEMBL
      E9QAK9
      Related
      ENSMUSP00000128433.3, ENSMUST00000168353.4
      Conserved Domains (2) summary
      smart00179
      Location:144183
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:37101
      EMI; EMI domain
    2. XM_036160852.1XP_036016745.1  epidermal growth factor-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      O35447, Q3UFB4, Q6GUQ1
      UniProtKB/TrEMBL
      B7ZP51, B9EJ41
      Conserved Domains (2) summary
      smart00179
      Location:144183
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:37101
      EMI; EMI domain