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    Ccdc85c coiled-coil domain containing 85C [ Mus musculus (house mouse) ]

    Gene ID: 668158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc85cprovided by MGI
    Official Full Name
    coiled-coil domain containing 85Cprovided by MGI
    Primary source
    MGI:MGI:3644008
    See related
    Ensembl:ENSMUSG00000084883 AllianceGenome:MGI:3644008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hhy; Gm265; Gm9010; EG668158
    Summary
    Involved in cerebral cortex development. Acts upstream of or within several processes, including Notch signaling pathway; establishment of cell polarity; and radial glial cell differentiation. Located in apical junction complex. Is expressed in brain; brain pia mater; brain subventricular zone; diencephalon; and telencephalon. Used to study hydrocephalus. Orthologous to human CCDC85C (coiled-coil domain containing 85C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 33.4), duodenum adult (RPKM 30.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc85c in Genome Data Viewer
    Location:
    12 F1; 12 59.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108169858..108244111, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108203599..108277852, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109157062-109157245 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109164383-109164658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109166259-109166489 Neighboring gene STARR-seq mESC enhancer starr_33230 Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109202967-109203154 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109231387-109231540 Neighboring gene STARR-seq mESC enhancer starr_33235 Neighboring gene SET domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E743 Neighboring gene cyclin K Neighboring gene STARR-positive B cell enhancer mm9_chr12:109513689-109513989 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109514813-109514922 Neighboring gene STARR-positive B cell enhancer mm9_chr12:109572195-109572495 Neighboring gene hedgehog interacting protein-like 1 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hemorrhagic hydrocephalus (hhy): a novel mutation on mouse chromosome 12. Kuwamura M, et al. Brain Res Dev Brain Res, 2004 Aug 18. PMID 15283996
    2. Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation. Xu J, et al. Cell Rep, 2023 Jul 25. PMID 37352102
    3. Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice. Mori N, et al. Am J Pathol, 2012 Jan. PMID 22056358
    4. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within radial glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 85C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159910.2 → NP_001153382.1  coiled-coil domain-containing protein 85C

      See identical proteins and their annotated locations for NP_001153382.1

      Status: VALIDATED

      Source sequence(s)
      AC122407, AC152059
      Consensus CDS
      CCDS49166.1
      UniProtKB/Swiss-Prot
      E9Q6B2
      Related
      ENSMUSP00000152421.2, ENSMUST00000222310.2
      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      DUF2216; Uncharacterized conserved proteins (DUF2216)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108169858..108244111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516161.4 → XP_006516224.1  coiled-coil domain-containing protein 85C isoform X4

      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family

    2. XM_006516160.4 → XP_006516223.1  coiled-coil domain-containing protein 85C isoform X3

      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family

    3. XM_006516159.4 → XP_006516222.1  coiled-coil domain-containing protein 85C isoform X2

      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family

    4. XM_006516158.4 → XP_006516221.1  coiled-coil domain-containing protein 85C isoform X1

      UniProtKB/TrEMBL
      A0A217FL83
      Related
      ENSMUSP00000125757.3, ENSMUST00000136175.3
      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6B2.1 GenPept UniProtKB/Swiss-Prot:E9Q6B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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