Hoxb7 homeobox B7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxb7provided by MGI
Official Full Name: homeobox B7provided by MGI
Primary source: MGI:MGI:96188
See related: Ensembl:ENSMUSG00000038721 AllianceGenome:MGI:96188
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hox-2.3
Summary: Enables DNA binding activity. Involved in positive regulation of branching involved in ureteric bud morphogenesis. Acts upstream of or within anterior/posterior pattern specification; embryonic skeletal system morphogenesis; and myeloid cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; nervous system; and neural ectoderm. Orthologous to human HOXB7 (homeobox B7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 24.5), genital fat pad adult (RPKM 20.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.82 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96176431..96180989)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96285604..96290163)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression resulted in significantly greater numbers of macroscopic lung metastatic cancer nodules
Title: Upregulated expression of HOXB7 in intrahepatic cholangiocarcinoma is associated with tumor cell metastasis and poor prognosis.
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 and Cdx2 in colon cancer cells.
Title: Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.
Results demonstrate HOXB7 as a master factor driving progenitors behavior lifetime, providing a better understanding of bone senescence and leading to an optimization of MSC performance.
Title: Mesenchymal progenitors aging highlights a miR-196 switch targeting HOXB7 as master regulator of proliferation and osteogenesis.
Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis
Title: Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis.
three short cis-acting sequences within this promoter segment that cooperate to induce high-level expression specifically in kidney collecting duct cells.
Title: Identification of two candidate collecting duct cell-specific cis-acting elements in the Hoxb-7 promoter region.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxb (e-PCR), detects polymorphism
- UniSTS:143378

Hoxb7 (e-PCR), detects polymorphism
- UniSTS:143384

AU048745 (e-PCR)
- UniSTS:145195

Hoxb7 (e-PCR), detects polymorphism
- UniSTS:536654

X06762 (e-PCR)
- UniSTS:125794

AA892263 (e-PCR)
- UniSTS:249957

D11Mit54 (e-PCR), detects polymorphism
- UniSTS:126601

AI325018 (e-PCR)
- UniSTS:165790

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: homeobox protein Hox-B7

Names: homeo box B7; homeobox protein Hox-2.3; homeobox protein MH-22B; homeobox protein MuB1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010460.2 → NP_034590.2 homeobox protein Hox-B7

See identical proteins and their annotated locations for NP_034590.2

Status: VALIDATED

Source sequence(s)

AK136706, AL645478

Consensus CDS

CCDS25294.1

UniProtKB/Swiss-Prot

A2A9Z9, P09024, Q3UW15

Related

ENSMUSP00000040121.7, ENSMUST00000049352.8

Conserved Domains (1) summary

pfam00046
Location:141 → 194

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

96176431..96180989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245592.2 → XP_030101452.1 homeobox protein Hox-B7 isoform X1

UniProtKB/Swiss-Prot

A2A9Z9, P09024, Q3UW15

Conserved Domains (1) summary

pfam00046
Location:141 → 194

Homeobox; Homeobox domain