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    Iho1 interactor of HORMAD1 1 [ Mus musculus (house mouse) ]

    Gene ID: 434438, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Iho1provided by MGI
    Official Full Name
    interactor of HORMAD1 1provided by MGI
    Primary source
    MGI:MGI:3612242
    See related
    Ensembl:ENSMUSG00000047220 AllianceGenome:MGI:3612242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc36
    Summary
    Involved in several processes, including meiosis I cell cycle process; regulation of homologous chromosome segregation; and spermatogenesis. Located in condensed nuclear chromosome. Is expressed in alimentary system; central nervous system; lung; temporal bone petrous part; and testis. Orthologous to human IHO1 (interactor of HORMAD1 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.9), CNS E18 (RPKM 0.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iho1 in Genome Data Viewer
    Location:
    9 F2; 9 59.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108280691..108309040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108403492..108431841, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene predicted gene, 25456 Neighboring gene cDNA sequence BC048562 Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation. Laroussi H, et al. EMBO J, 2023 Aug 15. PMID 37431931, Free PMC Article
    2. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436
    3. Principles of chromosome organization for meiotic recombination. Biot M, et al. Mol Cell, 2024 May 16. PMID 38657614
    4. Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4. Kumar R, et al. Life Sci Alliance, 2018 Dec. PMID 30569039, Free PMC Article
    5. Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Stanzione M, et al. Nat Cell Biol, 2016 Nov. PMID 27723721, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
      Title: Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interactor of HORMAD1 protein 1
    Names
    coiled-coil domain containing 36
    coiled-coil domain-containing protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135198.2 → NP_001128670.1  interactor of HORMAD1 protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001128670.1

      Status: VALIDATED

      Source sequence(s)
      AC161260
      Consensus CDS
      CCDS57701.1
      UniProtKB/Swiss-Prot
      Q6PDM4
      Related
      ENSMUSP00000075898.3, ENSMUST00000076592.4
      Conserved Domains (1) summary
      pfam15771
      Location:19 → 572
      IHO1; Interactor of HORMAD1 protein 1

    2. NM_001379658.1 → NP_001366587.1  interactor of HORMAD1 protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161260
      UniProtKB/Swiss-Prot
      Q6PDM4
      Conserved Domains (1) summary
      pfam15771
      Location:19 → 572
      IHO1; Interactor of HORMAD1 protein 1

    3. NM_001411369.1 → NP_001398298.1  interactor of HORMAD1 protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161260

    4. NM_001411370.1 → NP_001398299.1  interactor of HORMAD1 protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161260

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108280691..108309040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242895.2 → XP_011241197.1  interactor of HORMAD1 protein 1 isoform X1

      Conserved Domains (1) summary
      pfam15771
      Location:20 → 495
      IHO1; Interactor of HORMAD1 protein 1

    2. XM_011242896.2 → XP_011241198.1  interactor of HORMAD1 protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011241198.1

      Conserved Domains (1) summary
      pfam15771
      Location:1 → 385
      IHO1; Interactor of HORMAD1 protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDM4.3 GenPept UniProtKB/Swiss-Prot:Q6PDM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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