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    Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 [ Mus musculus (house mouse) ]

    Gene ID: 230145, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Galnt12provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 12provided by MGI
    Primary source
    MGI:MGI:2444664
    See related
    Ensembl:ENSMUSG00000039774 AllianceGenome:MGI:2444664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130206E10; galNAc-T12; pp-GaNTase; A630062B03Rik; pp-GaNTase 12; mpp-GalNAc-T12
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nervous system; and submandibular gland primordium. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 53.1), stomach adult (RPKM 17.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galnt12 in Genome Data Viewer
    Location:
    4 B1; 4 25.96 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (47091894..47123058)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (47091894..47123058)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:47033511-47033812 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 6 Neighboring gene uncharacterized LOC118568655 Neighboring gene STARR-seq mESC enhancer starr_10140 Neighboring gene predicted gene, 52731 Neighboring gene predicted gene 12426 Neighboring gene collagen, type XV, alpha 1 Neighboring gene predicted gene, 32317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Anks6 leads to YAP deficiency and liver abnormalities. Airik M, et al. Hum Mol Genet, 2020 Nov 4. PMID 32886109, Free PMC Article
    2. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
    3. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 12
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12
    polypeptide GalNAc transferase 12
    protein-UDP acetylgalactosaminyltransferase 12
    NP_766281.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172693.4 → NP_766281.1  polypeptide N-acetylgalactosaminyltransferase 12

      See identical proteins and their annotated locations for NP_766281.1

      Status: VALIDATED

      Source sequence(s)
      AK033638, AK043977, CK627557
      Consensus CDS
      CCDS18158.1
      UniProtKB/Swiss-Prot
      Q8BGT9
      UniProtKB/TrEMBL
      Q60GT3
      Related
      ENSMUSP00000045721.6, ENSMUST00000045041.12
      Conserved Domains (4) summary
      cd02510
      Location:134 → 428
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:129 → 424
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:442 → 571
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:440 → 569
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RNA

    1. NR_156438.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK043977, CK627557
      Related
      ENSMUST00000107744.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      47091894..47123058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003954907.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGT9.1 GenPept UniProtKB/Swiss-Prot:Q8BGT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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