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    Spatc1 spermatogenesis and centriole associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 74281, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spatc1provided by MGI
    Official Full Name
    spermatogenesis and centriole associated 1provided by MGI
    Primary source
    MGI:MGI:1921531
    See related
    Ensembl:ENSMUSG00000049653 AllianceGenome:MGI:1921531
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    speriolin; 1700084J23Rik
    Summary
    Enables gamma-tubulin binding activity. Located in centrosome and cytoplasm. Is expressed in 1-cell stage embryo; germ cell of testis; and spermatozoon. Orthologous to human SPATC1 (spermatogenesis and centriole associated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 104.4) See more
    Orthologs
    human all
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    Genomic context

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    See Spatc1 in Genome Data Viewer
    Location:
    15 D3; 15 35.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76150731..76176777)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76266531..76292577)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene microRNA 6953 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) Neighboring gene myocardial infraction associated transcript 2 Neighboring gene microRNA 3079 Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene STARR-seq mESC enhancer starr_39050 Neighboring gene STARR-positive B cell enhancer ABC_E7384 Neighboring gene exosome component 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Speriolin is a novel human and mouse sperm centrosome protein. Goto M, et al. Hum Reprod, 2010 Aug. PMID 20542897, Free PMC Article
    2. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. Goto M, et al. J Biol Chem, 2004 Oct 1. PMID 15280373
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144830

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    speriolin
    Names
    spermatogenesis and centriole-associated protein 1
    spermatogenic cell-specific Cdc20-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028852.1 → NP_083128.1  speriolin

      See identical proteins and their annotated locations for NP_083128.1

      Status: PROVISIONAL

      Source sequence(s)
      AB032199
      Consensus CDS
      CCDS27564.1
      UniProtKB/Swiss-Prot
      Q148B6, Q14AS6, Q76MV2, Q9D9F0
      UniProtKB/TrEMBL
      A0A0R4J0X4
      Related
      ENSMUSP00000073805.4, ENSMUST00000074173.4
      Conserved Domains (2) summary
      pfam15058
      Location:1 → 262
      Speriolin_N; Speriolin N terminus
      pfam15059
      Location:334 → 480
      Speriolin_C; Speriolin C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76150731..76176777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316766.2 → XP_017172255.1  speriolin isoform X4

      Conserved Domains (2) summary
      pfam15058
      Location:19 → 43
      Speriolin_N; Speriolin N-terminus
      pfam15059
      Location:115 → 261
      Speriolin_C; Speriolin C-terminus

    2. XM_017316762.2 → XP_017172251.1  speriolin isoform X1

      UniProtKB/Swiss-Prot
      Q148B6, Q14AS6, Q76MV2, Q9D9F0
      Conserved Domains (2) summary
      pfam15058
      Location:12 → 212
      Speriolin_N; Speriolin N-terminus
      pfam15059
      Location:284 → 430
      Speriolin_C; Speriolin C-terminus

    3. XM_017316764.3 → XP_017172253.1  speriolin isoform X2

      UniProtKB/Swiss-Prot
      Q148B6, Q14AS6, Q76MV2, Q9D9F0
      Conserved Domains (2) summary
      pfam15058
      Location:1 → 174
      Speriolin_N; Speriolin N-terminus
      pfam15059
      Location:246 → 392
      Speriolin_C; Speriolin C-terminus

    4. XM_017316768.2 → XP_017172257.1  speriolin isoform X5

      UniProtKB/Swiss-Prot
      Q148B6
      Conserved Domains (1) summary
      pfam15059
      Location:38 → 184
      Speriolin_C; Speriolin C-terminus

    5. XM_017316765.2 → XP_017172254.1  speriolin isoform X3

      Conserved Domains (2) summary
      pfam15058
      Location:1 → 125
      Speriolin_N; Speriolin N-terminus
      pfam15059
      Location:165 → 311
      Speriolin_C; Speriolin C-terminus

    6. XM_017316767.2 → XP_017172256.1  speriolin isoform X5

      UniProtKB/Swiss-Prot
      Q148B6
      Conserved Domains (1) summary
      pfam15059
      Location:38 → 184
      Speriolin_C; Speriolin C-terminus

    7. XM_030248802.1 → XP_030104662.1  speriolin isoform X5

      Conserved Domains (1) summary
      pfam15059
      Location:38 → 184
      Speriolin_C; Speriolin C-terminus

    8. XM_017316763.3 → XP_017172252.1  speriolin isoform X2

      UniProtKB/Swiss-Prot
      Q148B6, Q14AS6, Q76MV2, Q9D9F0
      Conserved Domains (2) summary
      pfam15058
      Location:1 → 174
      Speriolin_N; Speriolin N-terminus
      pfam15059
      Location:246 → 392
      Speriolin_C; Speriolin C-terminus

    9. XM_017316769.3 → XP_017172258.1  speriolin isoform X5

      UniProtKB/Swiss-Prot
      Q148B6
      Conserved Domains (1) summary
      pfam15059
      Location:38 → 184
      Speriolin_C; Speriolin C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q148B6.1 GenPept UniProtKB/Swiss-Prot:Q148B6

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