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    Xpo4 exportin 4 [ Mus musculus (house mouse) ]

    Gene ID: 57258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xpo4provided by MGI
    Official Full Name
    exportin 4provided by MGI
    Primary source
    MGI:MGI:1888526
    See related
    Ensembl:ENSMUSG00000021952 AllianceGenome:MGI:1888526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1721; B430309A01Rik
    Summary
    Predicted to enable nuclear export signal receptor activity and small GTPase binding activity. Predicted to be involved in positive regulation of protein export from nucleus and protein export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and retina. Orthologous to human XPO4 (exportin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.9), CNS E11.5 (RPKM 4.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xpo4 in Genome Data Viewer
    Location:
    14 C3; 14 30.11 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57814978..57906951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57577521..57668232, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene EEF1A alpha lysine methyltransferase 1 Neighboring gene RIKEN cDNA 1700039M10 gene Neighboring gene STARR-positive B cell enhancer ABC_E5445 Neighboring gene STARR-seq mESC enhancer starr_36813 Neighboring gene large tumor suppressor 2 Neighboring gene predicted gene, 26440 Neighboring gene STARR-seq mESC enhancer starr_36814 Neighboring gene predicted gene, 52140

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs. Chen L, et al. Nat Commun, 2022 Oct 1. PMID 36182935, Free PMC Article
    2. Exportin 4 DNA promoter methylation in liver fibrosis. Pan Z, et al. PLoS One, 2024. PMID 38722973, Free PMC Article
    3. Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivo. Vallis KA, et al. Radiat Res, 2002 Jan. PMID 11754636
    4. Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. Gontan C, et al. J Cell Biol, 2009 Apr 6. PMID 19349578, Free PMC Article
    5. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. Lipowsky G, et al. EMBO J, 2000 Aug 15. PMID 10944119, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exportin 4 DNA promoter methylation in liver fibrosis.
      Title: Exportin 4 DNA promoter methylation in liver fibrosis.
    2. Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs.
      Title: Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs.
    3. Exp4 (exportin 4) is an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors.
      Title: Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear export signal receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exportin-4
    Names
    exp4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368697.1 → NP_001355626.1  exportin-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154504, AC154675, AK084907
      UniProtKB/Swiss-Prot
      E9QLH3, Q6ZPJ4, Q9ESJ0

    2. NM_001368698.1 → NP_001355627.1  exportin-4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154504
      UniProtKB/TrEMBL
      Q3TQK5
      Conserved Domains (1) summary
      smart00913
      Location:37 → 103
      IBN_N; Importin-beta N-terminal domain

    3. NM_020506.2 → NP_065252.1  exportin-4 isoform 1

      See identical proteins and their annotated locations for NP_065252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154504, AC154675
      Consensus CDS
      CCDS56961.1
      UniProtKB/Swiss-Prot
      E9QLH3, Q6ZPJ4, Q9ESJ0
      UniProtKB/TrEMBL
      A0A0R4J254
      Related
      ENSMUSP00000133280.2, ENSMUST00000174545.9

    RNA

    1. NR_160870.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154504, AK163558

    2. NR_160871.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154504, AK021022

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      57814978..57906951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247900.2 → XP_030103760.1  exportin-4 isoform X2

      UniProtKB/Swiss-Prot
      E9QLH3, Q6ZPJ4, Q9ESJ0

    2. XM_036158768.1 → XP_036014661.1  exportin-4 isoform X1

      UniProtKB/Swiss-Prot
      E9QLH3, Q6ZPJ4, Q9ESJ0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESJ0.2 GenPept UniProtKB/Swiss-Prot:Q9ESJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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