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    Aldh1b1 aldehyde dehydrogenase 1 family, member B1 [ Mus musculus (house mouse) ]

    Gene ID: 72535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aldh1b1provided by MGI
    Official Full Name
    aldehyde dehydrogenase 1 family, member B1provided by MGI
    Primary source
    MGI:MGI:1919785
    See related
    Ensembl:ENSMUSG00000035561 AllianceGenome:MGI:1919785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700007F14Rik
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in ethanol catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; and liver. Orthologous to human ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 182.6), duodenum adult (RPKM 64.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aldh1b1 in Genome Data Viewer
    Location:
    4 B1; 4 24.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45799022..45804608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45799022..45804608)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31563 Neighboring gene STARR-seq mESC enhancer starr_10108 Neighboring gene STARR-seq mESC enhancer starr_10110 Neighboring gene predicted gene 12409 Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STARR-seq mESC enhancer starr_10113 Neighboring gene STRA6-like Neighboring gene STARR-seq mESC enhancer starr_10114 Neighboring gene coiled-coil domain containing 180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ALDH1B1 links alcohol consumption and diabetes. Singh S, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26086111, Free PMC Article
    2. Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice. Müller MF, et al. J Pathol, 2017 Apr. PMID 28026023
    3. The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss. Müller MF, et al. Exp Mol Pathol, 2018 Aug. PMID 29859945
    4. The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS. Sun N, et al. Sci Signal, 2024 Jan 9. PMID 38194477
    5. Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Giannios I, et al. Stem Cells, 2019 May. PMID 30681750, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
      Title: The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
    2. Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.
      Title: Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.
    3. We identified AMI-5, a protein methyltransferase inhibitor, as an Aldh1b1 inducer and showed that it can maintain Aldh1b1 expression in embryonic pancreas explants. This led to a selective reduction in endocrine specification. This effect was due to a downregulation of Ngn3, and it was mediated through Aldh1b1 since the effect was abolished in Aldh1b1 null pancreata.
      Title: Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression.
    4. Overexpression of Aldh1b1 is associated with pancreatic cancer development.
      Title: Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
    5. Aldehyde dehydrogenase has a critical role for beta cell development and functionality in mice
      Title: Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.
    6. show for the first time the functional in vivo role of ALDH1B1 in acetaldehyde metabolism and in maintaining glucose homeostasis
      Title: ALDH1B1 links alcohol consumption and diabetes.
    7. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
      Title: ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101971

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ethanol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase X, mitochondrial
    Names
    aldehyde dehydrogenase family 1 member B1
    NP_082546.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028270.4 → NP_082546.1  aldehyde dehydrogenase X, mitochondrial precursor

      See identical proteins and their annotated locations for NP_082546.1

      Status: VALIDATED

      Source sequence(s)
      AK153416, AW555370, CJ158368
      Consensus CDS
      CCDS18139.1
      UniProtKB/Swiss-Prot
      Q3UAH5, Q9CZS1
      Related
      ENSMUSP00000041260.5, ENSMUST00000044384.5
      Conserved Domains (2) summary
      cd07141
      Location:33 → 513
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
      PLN02466
      Location:22 → 518
      PLN02466; aldehyde dehydrogenase family 2 member

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45799022..45804608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZS1.1 GenPept UniProtKB/Swiss-Prot:Q9CZS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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