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    Zfp184 zinc finger protein 184 (Kruppel-like) [ Mus musculus (house mouse) ]

    Gene ID: 193452, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp184provided by MGI
    Official Full Name
    zinc finger protein 184 (Kruppel-like)provided by MGI
    Primary source
    MGI:MGI:1922244
    See related
    Ensembl:ENSMUSG00000006720 AllianceGenome:MGI:1922244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930500C15Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; respiratory system; retina nuclear layer; submandibular gland primordium; and tooth. Orthologous to human ZNF184 (zinc finger protein 184). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 4.6), CNS E14 (RPKM 3.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp184 in Genome Data Viewer
    Location:
    13 A3.1; 13 8.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22129223..22144961)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21945053..21960791)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA aspartic acid 12 (anticodon GTC) Neighboring gene nuclear encoded tRNA serine 8 (anticodon AGA) Neighboring gene Tu translation elongation factor, mitochondrial pseudogene Neighboring gene nuclear encoded tRNA lysine 22 (anticodon TTT) Neighboring gene STARR-positive B cell enhancer ABC_E7210 Neighboring gene nuclear encoded tRNA methionine 8 (anticodon CAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. Foronda M, et al. Cell Rep, 2014 Jul 24. PMID 25043184, Free PMC Article
    2. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC62472

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 184

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360886.1 → NP_001347815.1  zinc finger protein 184 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589879
      Conserved Domains (3) summary
      COG5048
      Location:88 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:212 → 232
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:560 → 584
      zf-H2C2_2; Zinc-finger double domain

    2. NM_183014.1 → NP_898835.1  zinc finger protein 184 isoform 1

      See identical proteins and their annotated locations for NP_898835.1

      Status: VALIDATED

      Source sequence(s)
      BC053084
      Consensus CDS
      CCDS26302.1
      UniProtKB/Swiss-Prot
      Q7TSH9
      Related
      ENSMUSP00000135173.2, ENSMUST00000176511.8
      Conserved Domains (4) summary
      smart00349
      Location:28 → 88
      KRAB; krueppel associated box
      COG5048
      Location:163 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:635 → 659
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      22129223..22144961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157919.1 → XP_036013812.1  zinc finger protein 184 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:131 → 602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 68
      KRAB; KRAB box
      pfam13465
      Location:603 → 627
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006516597.5 → XP_006516660.1  zinc finger protein 184 isoform X1

      See identical proteins and their annotated locations for XP_006516660.1

      UniProtKB/Swiss-Prot
      Q7TSH9
      Related
      ENSMUSP00000100043.2, ENSMUST00000102978.8
      Conserved Domains (4) summary
      smart00349
      Location:28 → 88
      KRAB; krueppel associated box
      COG5048
      Location:163 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:635 → 659
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030247204.2 → XP_030103064.1  zinc finger protein 184 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:88 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:212 → 232
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:560 → 584
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006516596.5 → XP_006516659.1  zinc finger protein 184 isoform X1

      See identical proteins and their annotated locations for XP_006516659.1

      UniProtKB/Swiss-Prot
      Q7TSH9
      Conserved Domains (4) summary
      smart00349
      Location:28 → 88
      KRAB; krueppel associated box
      COG5048
      Location:163 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:635 → 659
      zf-H2C2_2; Zinc-finger double domain

    5. XM_030247205.1 → XP_030103065.1  zinc finger protein 184 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:88 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:212 → 232
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:560 → 584
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSH9.1 GenPept UniProtKB/Swiss-Prot:Q7TSH9

    Gene LinkOut

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