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    Rbm38 RNA binding motif protein 38 [ Mus musculus (house mouse) ]

    Gene ID: 56190, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbm38provided by MGI
    Official Full Name
    RNA binding motif protein 38provided by MGI
    Primary source
    MGI:MGI:1889294
    See related
    Ensembl:ENSMUSG00000027510 AllianceGenome:MGI:1889294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Seb4; Rnpc1; Seb4l
    Summary
    Enables mRNA binding activity. Involved in regulation of myotube differentiation. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; limb; and sensory organ. Orthologous to human RBM38 (RNA binding motif protein 38). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 258.6), spleen adult (RPKM 239.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm38 in Genome Data Viewer
    Location:
    2 H3; 2 95.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172863722..172876527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173021891..173034734)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4526 Neighboring gene predicted gene, 52538 Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene STARR-positive B cell enhancer ABC_E6029 Neighboring gene STARR-seq mESC enhancer starr_06607 Neighboring gene ribonucleic acid export 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172852363-172852564 Neighboring gene VISTA enhancer mm92 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172872098-172872385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172879441-172879628 Neighboring gene predicted gene, 36337 Neighboring gene predicted gene, 36462 Neighboring gene predicted gene, 36417

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice. van den Hoogenhof MMG, et al. PLoS One, 2017. PMID 28850611, Free PMC Article
    2. The RNA-binding protein RBM24 regulates lipid metabolism and SLC7A11 mRNA stability to modulate ferroptosis and inflammatory response. Zhang J, et al. Front Cell Dev Biol, 2022. PMID 36478739, Free PMC Article
    3. Expression of the RNA recognition motif-containing protein SEB-4 during Xenopus embryonic development. Fetka I, et al. Mech Dev, 2000 Jun. PMID 10842088
    4. Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38. Sun W, et al. Genes Dev, 2021 Apr 1. PMID 33664057, Free PMC Article
    5. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Zhang J, et al. Proc Natl Acad Sci U S A, 2014 Dec 30. PMID 25512531, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
      Title: Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
    2. Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.
      Title: Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.
    3. Rbm38 promotes lymphomagenesis.Rbm38 was required for Pten expression via stabilization of Pten mRNA through an AU-rich element in its 3'UTR.Rbm38 controls T-cell lymphomagenesis by jointly modulating mutant p53 and Pten.
      Title: Genetic Ablation of Rbm38 Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN.
    4. The hearts of Rbm38 -/- mice were mildly hypertrophic, but cardiac function was not affected. Furthermore, Rbm38 deficiency did not affect cardiac remodeling (i.e. hypertrophy, LV dilation and fibrosis) or performance (i.e. fractional shortening) after pressure-overload induced by transverse aorta constriction.
      Title: The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice.
    5. Rbm38 deficiency markedly decreases the tumor penetrance in mice heterozygous for p53 via enhanced p53 expression.
      Title: Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors.
    6. knockdown of MIC-1 can decrease RNPC1-induced cell growth suppression.
      Title: RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability.
    7. knockdown of p73 or p21, another target of RNPC1, attenuates the inhibitory effect of RNPC1 on cell proliferation and premature senescence, whereas combined knockdown of p73 and p21 completely abolishes it
      Title: p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability.
    8. a novel mechanism by which HuR is regulated by RNPC1 via mRNA stability and HuR is a mediator of RNPC1-induced growth suppression.
      Title: The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation.
    9. loss of RNPC1 in mouse embryonic fibroblasts increased the level of p53 protein, leading to enhanced premature senescence in a p53-dependent manner
      Title: Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myotube differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 38
    Names
    RNA-binding region (RNP1, RRM) containing 1
    RNA-binding region-containing protein 1
    seb4 mRNA
    ssDNA-binding protein SEB4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421599.1 → NP_001408528.1  RNA-binding protein 38 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928599

    2. NM_001421600.1 → NP_001408529.1  RNA-binding protein 38 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928599

    3. NM_001421601.1 → NP_001408530.1  RNA-binding protein 38 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928599

    4. NM_001421602.1 → NP_001408531.1  RNA-binding protein 38 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928599

    5. NM_019547.3 → NP_062420.2  RNA-binding protein 38 isoform a

      See identical proteins and their annotated locations for NP_062420.2

      Status: VALIDATED

      Source sequence(s)
      AL928599
      Consensus CDS
      CCDS17139.1
      UniProtKB/Swiss-Prot
      Q5U418, Q62176, Q922Z2
      Related
      ENSMUSP00000029014.10, ENSMUST00000029014.16
      Conserved Domains (1) summary
      cd12384
      Location:32 → 107
      RRM_RBM24_RBM38_like; RNA recognition motif in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172863722..172876527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62176.2 GenPept UniProtKB/Swiss-Prot:Q62176

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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