Fsd2 fibronectin type III and SPRY domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fsd2provided by MGI
Official Full Name: fibronectin type III and SPRY domain containing 2provided by MGI
Primary source: MGI:MGI:2444310
See related: Ensembl:ENSMUSG00000038663 AllianceGenome:MGI:2444310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spryd1; 9830160G03Rik
Summary: Predicted to be located in nucleus; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is expressed in hindlimb long bone and tarsus. Orthologous to human FSD2 (fibronectin type III and SPRY domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 56.7), mammary gland adult (RPKM 6.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 45.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (81184102..81216729, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (81534354..81566981, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data identify a novel muscle-expressed TRIM-related protein minispryn, encoded by Fsd2, that has extensive sequence similarity with the C-terminus of Cmya5. They appear to have originated by a chromosomal duplication and are found within evolutionarily-conserved gene clusters on different chromosomes. Both proteins co-localize with RyR2 at the junctional sarcoplasmic reticulum of isolated cardiomyocytes.
Title: Ryanodine receptors are part of the myospryn complex in cardiac muscle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fibronectin type III and SPRY domain-containing protein 2

Names: SPRY domain containing 1; SPRY domain-containing protein 1; minispryn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172904.2 → NP_766492.2 fibronectin type III and SPRY domain-containing protein 2

See identical proteins and their annotated locations for NP_766492.2

Status: VALIDATED

Source sequence(s)

AK028142, AK036674, BY067791

Consensus CDS

CCDS80743.1

UniProtKB/Swiss-Prot

A0A140T8J1, E9QMV0, Q8BZ52

Related

ENSMUSP00000047775.7, ENSMUST00000042318.6

Conserved Domains (4) summary

smart00060
Location:339 → 424

FN3; Fibronectin type 3 domain

cd00063
Location:436 → 528

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl02614
Location:532 → 707

SPRY; SPRY domain

cl25602
Location:174 → 290

DUF3552; Domain of unknown function (DUF3552)