Rnf11 ring finger protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf11provided by MGI
Official Full Name: ring finger protein 11provided by MGI
Primary source: MGI:MGI:1352759
See related: Ensembl:ENSMUSG00000028557 AllianceGenome:MGI:1352759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human RNF11 (ring finger protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 155.5), ovary adult (RPKM 53.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 51.29 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (109310054..109333702, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (109452857..109476505, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.
Title: Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.
Microglial RNF11 is a negative regulator of NF-kappaB signalling pathway and could be a strong potential target for modulating inflammatory responses in neurodegenerative diseases.
Title: RNF11 modulates microglia activation through NF-κB signalling cascade.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rnf11 (e-PCR), detects polymorphism
- UniSTS:531321

RH126050 (e-PCR)
- UniSTS:162762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RING finger protein 11

Names: NEDD4 WW domain-binding protein 2; sid 1669

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431265.1 → NP_001418194.1 RING finger protein 11

Status: VALIDATED

Source sequence(s)

AL627446, AL669905

UniProtKB/Swiss-Prot

B1AU36, B1AU37, Q9EQI1, Q9QYK7
NM_013876.4 → NP_038904.1 RING finger protein 11

See identical proteins and their annotated locations for NP_038904.1

Status: VALIDATED

Source sequence(s)

AL669905

Consensus CDS

CCDS18464.1

UniProtKB/Swiss-Prot

B1AU36, B1AU37, Q9EQI1, Q9QYK7

UniProtKB/TrEMBL

Z4YLT8

Related

ENSMUSP00000030284.4, ENSMUST00000030284.10

Conserved Domains (1) summary

cd16468
Location:98 → 140

RING-H2_RNF11; RING finger, H2 subclass, found in RING finger protein 11 (RNF11) and similar proteins