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    Zpbp2 zona pellucida binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 69376, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zpbp2provided by MGI
    Official Full Name
    zona pellucida binding protein 2provided by MGI
    Primary source
    MGI:MGI:1916626
    See related
    Ensembl:ENSMUSG00000017195 AllianceGenome:MGI:1916626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZPBPL; 1700017D11Rik; 2610022C02Rik
    Summary
    Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; membrane lipid metabolic process; and regulation of gene expression. Located in acrosomal vesicle and cell body. Part of zona pellucida receptor complex. Is expressed in lung. Orthologous to human ZPBP2 (zona pellucida binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 85.4) See more
    Orthologs
    human all
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    Genomic context

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    See Zpbp2 in Genome Data Viewer
    Location:
    11 D; 11 61.97 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98441923..98449491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98551097..98558665)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene migration and invasion enhancer 1 Neighboring gene STARR-seq mESC enhancer starr_30668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320467-98320833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320999-98321108 Neighboring gene growth factor receptor bound protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E11772 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106 Neighboring gene STARR-positive B cell enhancer ABC_E7058 Neighboring gene VISTA enhancer mm503 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98388491-98388674 Neighboring gene STARR-positive B cell enhancer ABC_E8880 Neighboring gene STARR-positive B cell enhancer ABC_E8450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98412942-98413125 Neighboring gene predicted gene, 38981 Neighboring gene predicted gene, 31460

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance. Youssef M, et al. J Pharmacol Exp Ther, 2020 Jun. PMID 32273303
    2. Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock. Chang ML, et al. PLoS One, 2019. PMID 31560728, Free PMC Article
    3. Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Kanagaratham C, et al. Mamm Genome, 2018 Apr. PMID 29536159
    4. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
    5. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, et al. J Biol Chem, 2011 Oct 21. PMID 21880732, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107119

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within membrane lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zona pellucida receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zona pellucida-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166494.1 → NP_001159966.1  zona pellucida-binding protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001159966.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 3 and 4 both encode isoform 3.
      Source sequence(s)
      AK006058, AL591125, BC089476
      Consensus CDS
      CCDS48903.1
      UniProtKB/TrEMBL
      A2A4X9
      Related
      ENSMUSP00000103133.2, ENSMUST00000107509.8
      Conserved Domains (1) summary
      pfam07354
      Location:1 → 272
      Sp38; Zona-pellucida-binding protein (Sp38)

    2. NM_001166495.1 → NP_001159967.1  zona pellucida-binding protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001159967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 3 and 4 both encode isoform 3.
      Source sequence(s)
      AK006058, AL591125, BC089476
      Consensus CDS
      CCDS48903.1
      UniProtKB/TrEMBL
      A2A4X9
      Related
      ENSMUSP00000103135.2, ENSMUST00000107511.8
      Conserved Domains (1) summary
      pfam07354
      Location:1 → 272
      Sp38; Zona-pellucida-binding protein (Sp38)

    3. NM_027061.2 → NP_081337.2  zona pellucida-binding protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_081337.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK006058, AL591125, BC089476
      Consensus CDS
      CCDS25353.1
      UniProtKB/Swiss-Prot
      A2A4Y0, Q6X785, Q6X786, Q9DA91
      UniProtKB/TrEMBL
      A2A4X9
      Related
      ENSMUSP00000017339.6, ENSMUST00000017339.12
      Conserved Domains (1) summary
      pfam07354
      Location:55 → 326
      Sp38; Zona-pellucida-binding protein (Sp38)

    4. NM_199419.3 → NP_955451.2  zona pellucida-binding protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_955451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL591125, BC089476
      Consensus CDS
      CCDS25354.1
      UniProtKB/TrEMBL
      Q5FWC7
      Related
      ENSMUSP00000079822.7, ENSMUST00000081033.13
      Conserved Domains (1) summary
      pfam07354
      Location:55 → 253
      Sp38; Zona-pellucida-binding protein (Sp38)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98441923..98449491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6X786.2 GenPept UniProtKB/Swiss-Prot:Q6X786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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