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    Or5k14 olfactory receptor family 5 subfamily K member 14 [ Mus musculus (house mouse) ]

    Gene ID: 258998, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Or5k14provided by MGI
    Official Full Name
    olfactory receptor family 5 subfamily K member 14provided by MGI
    Primary source
    MGI:MGI:3030011
    See related
    Ensembl:ENSMUSG00000063137 AllianceGenome:MGI:3030011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Olfr176; Olfr177; MOR184-7; MOR184-8; GA_x54KRFPKG5P-55043245-55042289
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See Or5k14 in Genome Data Viewer
    Location:
    16; 16 C1.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58689766..58693511, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58869403..58873148, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41103 Neighboring gene olfactory receptor family 5 subfamily K member 1 Neighboring gene STARR-seq mESC enhancer starr_41104 Neighboring gene olfactory receptor family 5 subfamily K member 8 Neighboring gene olfactory receptor family 5 subfamily J member 15 Neighboring gene olfactory receptor family 5 subfamily K member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. Lyons DB, et al. Cell Rep, 2014 Nov 6. PMID 25437545, Free PMC Article
    2. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    3. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    4. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article
    5. A unified nomenclature for vertebrate olfactory receptors. Olender T, et al. BMC Evol Biol, 2020 Apr 15. PMID 32295537, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olfactory receptor 177
    Names
    GA_x54KRFPKG5P-55091371-55090442
    olfactory receptor 176
    olfactory receptor MOR184-7
    olfactory receptor MOR184-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146993.1 → NP_667204.1  olfactory receptor 177 isoform 1

      See identical proteins and their annotated locations for NP_667204.1

      Status: PROVISIONAL

      Source sequence(s)
      AY073095
      UniProtKB/TrEMBL
      Q8VGQ1, Q8VGQ4

    2. NM_146996.2 → NP_667207.2  olfactory receptor 177 isoform 2

      See identical proteins and their annotated locations for NP_667207.2

      Status: VALIDATED

      Source sequence(s)
      AC154545
      Consensus CDS
      CCDS49880.1
      UniProtKB/TrEMBL
      E9Q7W1, Q7TS50
      Related
      ENSMUSP00000072631.3, ENSMUST00000072853.3
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      58689766..58693511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249118.1 → XP_030104978.1  olfactory receptor 177 isoform X1

      UniProtKB/TrEMBL
      Q7TS50
      Conserved Domains (2) summary
      cd14964
      Location:26 → 52
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25 → 303
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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