Gvin1 GTPase, very large interferon inducible 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gvin1provided by MGI
Official Full Name: GTPase, very large interferon inducible 1provided by MGI
Primary source: MGI:MGI:1921808
See related: Ensembl:ENSMUSG00000045868 AllianceGenome:MGI:1921808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VLIG; Iigs1; VLIG-1; 9130002C22Rik; 9830104F22Rik
Summary: Predicted to enable GTP binding activity. Predicted to be located in cytosol and nucleus. Orthologous to human GVINP1 (GTPase, very large interferon inducible pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in large intestine adult (RPKM 3.4), spleen adult (RPKM 2.8) and 23 other tissues See more
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Genomic context

Location:: 7 E3; 7 55.98 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (105755742..105814547, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (106156535..106215340, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VLIG-1 belongs to a GTPase superfamily associated with the interferon response, and its similarities to members of the p47, p65, and Mx GTPase families justifies a concentrated attempt to implicate VLIG proteins in resistance to infectious disease.
Title: A giant GTPase, very large inducible GTPase-1, is inducible by IFNs.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon-induced very large GTPase 1

Names: interferon inducible GTPase 1; very large-inducible GTPase-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039160.2 → NP_001034249.2 interferon-induced very large GTPase 1

See identical proteins and their annotated locations for NP_001034249.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two internal exons in the 5' UTR and encodes the same protein, compared to variant 1.

Source sequence(s)

AC165356

Consensus CDS

CCDS21663.1

UniProtKB/TrEMBL

L7N451

Related

ENSMUSP00000006667.4, ENSMUST00000006667.11

Conserved Domains (3) summary

PRK00247
Location:72 → 139

PRK00247; putative inner membrane protein translocase component YidC; Validated

TIGR02168
Location:1206 → 1432

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl38936
Location:1485 → 1562

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_029000.3 → NP_083276.2 interferon-induced very large GTPase 1

See identical proteins and their annotated locations for NP_083276.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC165356

Consensus CDS

CCDS21663.1

UniProtKB/TrEMBL

L7N451

Related

ENSMUSP00000138950.2, ENSMUST00000183409.2

Conserved Domains (3) summary

PRK00247
Location:72 → 139

PRK00247; putative inner membrane protein translocase component YidC; Validated

TIGR02168
Location:1206 → 1432

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl38936
Location:1485 → 1562

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

105755742..105814547 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312356.1 → XP_017167845.1 interferon-induced very large GTPase 1 isoform X1

UniProtKB/TrEMBL

L7N451

Conserved Domains (3) summary

PRK00247
Location:72 → 139

PRK00247; putative inner membrane protein translocase component YidC; Validated

TIGR02168
Location:1206 → 1432

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl38936
Location:1485 → 1562

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases