Atf1 activating transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atf1provided by MGI
Official Full Name: activating transcription factor 1provided by MGI
Primary source: MGI:MGI:1298366
See related: Ensembl:ENSMUSG00000023027 AllianceGenome:MGI:1298366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Part of ATF1-ATF4 transcription factor complex. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Orthologous to human ATF1 (activating transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 24.0), liver E14 (RPKM 14.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.22 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100125729..100159129)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100227859..100261248)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
Title: ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
Testicular localization of activating transcription factor 1 and its potential function during spermatogenesisdagger.
Title: Testicular localization of activating transcription factor 1 and its potential function during spermatogenesis†.
Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.
Title: Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.
the HSF1 complex, including BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), is formed in a manner dependent on the phosphorylation of ATF1
Title: ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex.
conclude that HO-1 regulates DC maturation and function by modulating the p38 MAPK-CREB/ATF1 signaling axis
Title: Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB/ATF1 signaling.
Dehydroepiandrosterone sulfate (DHEAS)-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor, since silencing of Gnalpha11 leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB.
Title: Dehydroepiandrosterone sulfate mediates activation of transcription factors CREB and ATF-1 via a Gα11-coupled receptor in the spermatogenic cell line GC-2.
indicate that dysregulation of p38 MAPK-CREB/ATF1 signaling axis underlies the altered function and phenotype in Nrf2-deficient DCs
Title: Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
Title: EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
miR-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
Title: MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1.
ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation.
Title: Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136283 (e-PCR)
- UniSTS:210276

NoName (e-PCR)
- UniSTS:224484

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cAMP/PKA signal transduction	IEA Inferred from Electronic Annotation more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to cobalt ion	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ATF1-ATF4 transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATF1-ATF4 transcription factor complex	ISO Inferred from Sequence Orthology more info
part_of ATF4-CREB1 transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-1

Names: TCR-ATF1; cAMP-dependent transcription factor ATF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410369.1 → NP_001397298.1 cyclic AMP-dependent transcription factor ATF-1

Status: VALIDATED

Source sequence(s)

AC124479

UniProtKB/Swiss-Prot

P81269
NM_001410370.1 → NP_001397299.1 cyclic AMP-dependent transcription factor ATF-1

Status: VALIDATED

Source sequence(s)

AC124479

UniProtKB/Swiss-Prot

P81269
NM_007497.4 → NP_031523.3 cyclic AMP-dependent transcription factor ATF-1

See identical proteins and their annotated locations for NP_031523.3

Status: VALIDATED

Source sequence(s)

AC124479

Consensus CDS

CCDS27832.1

UniProtKB/Swiss-Prot

P81269

UniProtKB/TrEMBL

Q9CWS2

Related

ENSMUSP00000023769.5, ENSMUST00000023769.11

Conserved Domains (2) summary

cd14690
Location:213 → 267

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:48 → 82

pKID; pKID domain