Rhobtb1 Rho-related BTB domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhobtb1provided by MGI
Official Full Name: Rho-related BTB domain containing 1provided by MGI
Primary source: MGI:MGI:1916538
See related: Ensembl:ENSMUSG00000019944 AllianceGenome:MGI:1916538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700008H16Rik; 3110048G13Rik
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and stomach. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in heart adult (RPKM 5.9), ovary adult (RPKM 4.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 36.04 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (68987106..69127621)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (69151058..69291791)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RhoBTB1 protected from hypertension, vascular smooth muscle dysfunction, and arterial stiffness in at least two models of hypertension.
Title: RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236374

AI173445 (e-PCR)
- UniSTS:159988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081347.1 → NP_001074816.1 rho-related BTB domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC117209

Consensus CDS

CCDS35930.1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Related

ENSMUSP00000020101.6, ENSMUST00000020101.12

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_001252636.1 → NP_001239565.1 rho-related BTB domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC117209, AK005770

Consensus CDS

CCDS35930.1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Related

ENSMUSP00000132068.2, ENSMUST00000164034.8

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_001252637.1 → NP_001239566.1 rho-related BTB domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC117209, BB611014, BC137646

Consensus CDS

CCDS35930.1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Related

ENSMUSP00000065095.8, ENSMUST00000067908.14

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_001252638.1 → NP_001239567.1 rho-related BTB domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC117209, BC144800

UniProtKB/TrEMBL

B7ZMU4, Q6A003

Conserved Domains (3) summary

cd18530
Location:472 → 571

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:344 → 469

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

68987106..69127621

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514049.5 → XP_006514112.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_006514048.5 → XP_006514111.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_036155982.1 → XP_036011875.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_006514051.5 → XP_006514114.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B2RPX3, Q9DAK3

UniProtKB/TrEMBL

Q499C9

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_006514054.2 → XP_006514117.1 rho-related BTB domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

B7ZMU4, Q6A003

Conserved Domains (3) summary

cd18530
Location:472 → 571

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:344 → 469

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006514052.5 → XP_006514115.1 rho-related BTB domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

B7ZMU4, Q6A003

Conserved Domains (3) summary

cd18530
Location:472 → 571

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:344 → 469

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006514053.5 → XP_006514116.1 rho-related BTB domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

B7ZMU4, Q6A003

Conserved Domains (3) summary

cd18530
Location:472 → 571

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:344 → 469

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036155983.1 → XP_036011876.1 rho-related BTB domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

Q6A003

Conserved Domains (3) summary

cd18530
Location:443 → 542

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:315 → 440

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:10 → 58

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases