PURPL p53 upregulated regulator of p53 levels [Homo sapiens (human)] - Gene

Summary

Official Symbol: PURPLprovided by HGNC
Official Full Name: p53 upregulated regulator of p53 levelsprovided by HGNC
Primary source: HGNC:HGNC:48995
See related: Ensembl:ENSG00000250337 AllianceGenome:HGNC:48995
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC01021
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5p14.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (27472292..27496401)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (27577952..27602067)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (27472399..27496508)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer.
Title: LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer.
Long non-coding RNA p53 upregulated regulator of p53 levels (PURPL) promotes the development of gastric cancer.
Title: Long non-coding RNA p53 upregulated regulator of p53 levels (PURPL) promotes the development of gastric cancer.
High PURPL expression is associated with gastric cancer.
Title: Overexpression of PURPL and downregulation of NONHSAT062994 as potential biomarkers in gastric cancer.
Silencing of PURPL inhibited liver cancer cells proliferation, blocked cell cycle progression, and promoted apoptosis. Most importantly, PURPL expression was negatively correlated with p53 mRNA expression.
Title: Long noncoding RNA PURPL promotes cell proliferation in liver cancer by regulating p53.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Other Names

RP11-46C20.1
long intergenic non-protein coding RNA 1021

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.