U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ppp1r9b protein phosphatase 1, regulatory subunit 9B [ Mus musculus (house mouse) ]

    Gene ID: 217124, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r9bprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 9Bprovided by MGI
    Primary source
    MGI:MGI:2387581
    See related
    Ensembl:ENSMUSG00000038976 AllianceGenome:MGI:2387581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPL; Spn
    Summary
    Predicted to enable several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to morphine; regulation of opioid receptor signaling pathway; and regulation of postsynapse assembly. Acts upstream of or within several processes, including actin filament organization; calcium-mediated signaling; and dendrite development. Located in cortical actin cytoskeleton and filopodium. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human PPP1R9B (protein phosphatase 1 regulatory subunit 9B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 75.4), cortex adult (RPKM 71.9) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp1r9b in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94882038..94897724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94991212..95006898)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:94798366-94798667 Neighboring gene collagen, type I, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_30476 Neighboring gene sarcoglycan, alpha (dystrophin-associated glycoprotein) Neighboring gene STARR-positive B cell enhancer ABC_E7047 Neighboring gene H1.9 linker histone Neighboring gene STARR-seq mESC enhancer starr_30478 Neighboring gene STARR-seq mESC enhancer starr_30479 Neighboring gene STARR-positive B cell enhancer ABC_E3995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94859496-94859731 Neighboring gene predicted gene, 51875 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 2 Neighboring gene predicted gene, 53200

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC38940

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D2 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables D2 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within actin filament organization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in developmental process involved in reproduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male mating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to actin cortical patch ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of opioid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reproductive system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to L-phenylalanine derivative IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to kainic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to prostaglandin E IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic side of dendritic spine plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of dendritic spine plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine neck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine neck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spine apparatus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurabin-2
    Names
    neurabin-II
    spinophilin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172261.3NP_758465.2  neurabin-2

      See identical proteins and their annotated locations for NP_758465.2

      Status: VALIDATED

      Source sequence(s)
      AI841686, AY508450
      Consensus CDS
      CCDS25268.1
      UniProtKB/Swiss-Prot
      Q6R891, Q8K0X7
      Related
      ENSMUSP00000041732.6, ENSMUST00000038696.12
      Conserved Domains (3) summary
      smart00228
      Location:493582
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam07106
      Location:682763
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      cl23943
      Location:745811
      PCRF; PCRF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94882038..94897724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)