Wdr82 WD repeat domain containing 82 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr82provided by MGI
Official Full Name: WD repeat domain containing 82provided by MGI
Primary source: MGI:MGI:1924555
See related: Ensembl:ENSMUSG00000020257 AllianceGenome:MGI:1924555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDW5/WDR82; 9430077D24Rik
Summary: Enables chromatin binding activity. Involved in RNA catabolic process and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in early conceptus and ovary. Orthologous to human WDR82 (WD repeat domain 82). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 44.3), whole brain E14.5 (RPKM 43.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106048098..106068905)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106170925..106191706)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by interfering mitochondrial oxidative phosphorylation and glycolysis.
Title: WD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by interfering mitochondrial oxidative phosphorylation and glycolysis.
the result of a blocked WDR82 consists of stunted embryonic development and death. Thus, WDR82 can be considered a key epigenetic regulation-related factor crucial in the normal growth and development of embryos.
Title: WDR82, a key epigenetics-related factor, plays a crucial role in normal early embryonic development in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2493 (e-PCR), detects polymorphism
- UniSTS:38103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription termination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in lncRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lncRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription, elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription, elongation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lncRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lncRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in nuclear RNA surveillance	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear RNA surveillance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	ISO Inferred from Sequence Orthology more info
part_of PTW/PP1 phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	IEA Inferred from Electronic Annotation more info
part_of Set1C/COMPASS complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029896.1 → NP_084172.1 WD repeat-containing protein 82

See identical proteins and their annotated locations for NP_084172.1

Status: VALIDATED

Source sequence(s)

AK037620, AK159240, AK162537, AW044996, CK621157, CN722892

Consensus CDS

CCDS40754.1

UniProtKB/Swiss-Prot

Q8BFQ4, Q8K2G5, Q8VEE8

UniProtKB/TrEMBL

B2RXQ8

Related

ENSMUSP00000020490.6, ENSMUST00000020490.13

Conserved Domains (2) summary

cd00200
Location:15 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:24 → 61

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

106048098..106068905

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244715.2 → XP_030100575.1 WD repeat-containing protein 82 isoform X1

Conserved Domains (2) summary

sd00039
Location:9 → 48

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 156

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...