PDE9A phosphodiesterase 9A [Homo sapiens (human)] - Gene

Summary

Official Symbol: PDE9Aprovided by HGNC
Official Full Name: phosphodiesterase 9Aprovided by HGNC
Primary source: HGNC:HGNC:8795
See related: Ensembl:ENSG00000160191 MIM:602973; AllianceGenome:HGNC:8795
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSPDE9A2
Summary: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (42653621..42775509)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (41042071..41163988)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (44073731..44195619)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.
Title: Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.
Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.
Title: Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.
PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.
Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer
Title: Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors.
In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory.
Title: Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5.
Title: Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study.
Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin and CD11b adhesion molecules.
Title: Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: Poor replication of candidate genes for major depressive disorder using genome-wide association data.
PDE9A, is unlikely to play an important role in antidepressant outcome in this sample
Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of phosphodiesterase 9A (PDE9A) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS_CEB239 (e-PCR)
- UniSTS:255244

SHGC-105989 (e-PCR)
- UniSTS:169552

SHGC-87675 (e-PCR)
- UniSTS:63583

IB381 (e-PCR)
- UniSTS:45160

SHGC-57530 (e-PCR)
- UniSTS:12937

D21S1411 (e-PCR), detects polymorphism
- UniSTS:19353

D21S113 (e-PCR)
- UniSTS:147879

RH78209 (e-PCR)
- UniSTS:66757

D21S1974 (e-PCR)
- UniSTS:7638

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	TAS Traceable Author Statement more info	PubMed
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cGMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle hypertrophy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Names: CGMP-specific 3',5'-cyclic phosphodiesterase type 9; phosphodiesterase PDE9A21

NP_001001567.1

EC 3.1.4.35

NP_001001568.1

EC 3.1.4.35

NP_001001569.1

EC 3.1.4.35

NP_001001570.1

EC 3.1.4.35

NP_001001571.1

EC 3.1.4.35

NP_001001572.1

EC 3.1.4.35

NP_001001573.1

EC 3.1.4.35

NP_001001574.1

EC 3.1.4.35

NP_001001575.1

EC 3.1.4.35

NP_001001576.1

EC 3.1.4.35

NP_001001577.1

EC 3.1.4.35

NP_001001578.1

EC 3.1.4.35

NP_001001579.1

EC 3.1.4.35

NP_001001580.1

EC 3.1.4.35

NP_001001581.1

EC 3.1.4.35

NP_001001582.1

EC 3.1.4.35

NP_001001583.1

EC 3.1.4.35

NP_001001584.1

EC 3.1.4.35

NP_001001585.1

EC 3.1.4.35

NP_001302462.1

EC 3.1.4.35

NP_002597.1

EC 3.1.4.35

XP_011527900.1

EC 3.1.4.35

XP_011527902.1

EC 3.1.4.35

XP_016883855.1

EC 3.1.4.35

XP_054180516.1

EC 3.1.4.35

XP_054180517.1

EC 3.1.4.35

XP_054180518.1

EC 3.1.4.35

XP_054180519.1

EC 3.1.4.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047067.1 RefSeqGene

Range

4870..126758

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001001567.2 → NP_001001567.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but lacks an internal segment compared to isoform a.

Source sequence(s)

AF048837, AF067223, AF067224, AI492065, AP001626, BC009047

Consensus CDS

CCDS33568.1

UniProtKB/TrEMBL

A0A0S2Z4A3

Related

ENSP00000335242.4, ENST00000335512.8

Conserved Domains (1) summary

pfam00233
Location:251 → 479

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001568.2 → NP_001001568.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. The resulting predicted isoform (c) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AF048837, AF067223, AF067225, AI492065, AP001626, AY196305, BC009047

Consensus CDS

CCDS42946.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381280.3, ENST00000398224.3

Conserved Domains (1) summary

pfam00233
Location:184 → 412

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001569.2 → NP_001001569.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks four alternate exons compared to variant 1. The resulting predicted isoform (d) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AF048837, AF067223, AF067226, AI492065, AP001626, AY196305, BC009047

Consensus CDS

CCDS33571.1

UniProtKB/TrEMBL

A0A0S2Z475

Related

ENSP00000344730.3, ENST00000349112.7

Conserved Domains (1) summary

pfam00233
Location:183 → 411

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001570.2 → NP_001001570.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate exon and lacks two others compared to variant 1. The resulting isoform (e) has the same N- and C-termini but differs in an internal segment compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196299, BC009047

Consensus CDS

CCDS33567.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000369685.2, ENST00000380328.6

Conserved Domains (1) summary

pfam00233
Location:258 → 486

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001571.2 → NP_001001571.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting predicted isoform (f) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196300, BC009047

Consensus CDS

CCDS42943.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381289.3, ENST00000398234.7

Conserved Domains (1) summary

pfam00233
Location:210 → 438

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001572.2 → NP_001001572.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks four alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196301, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000467403.5

Conserved Domains (1) summary

pfam00233
Location:104 → 332

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001573.2 → NP_001001573.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196302, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000490803.5

Conserved Domains (1) summary

pfam00233
Location:104 → 332

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001574.2 → NP_001001574.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (h) has the same N- and C-termini but lacks two internal segments compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196303, BC009047

Consensus CDS

CCDS42941.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381291.3, ENST00000398236.7

Conserved Domains (1) summary

pfam00233
Location:225 → 453

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001575.2 → NP_001001575.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks five alternate exons compared to variant 1. The resulting predicted isoform (i) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196304, BC009047

Consensus CDS

CCDS42947.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381283.3, ENST00000398227.7

Conserved Domains (1) summary

pfam00233
Location:151 → 379

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001576.2 → NP_001001576.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks five alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196305, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000495521.5

Conserved Domains (1) summary

pfam00233
Location:94 → 322

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001577.2 → NP_001001577.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks four alternate exons compared to variant 1. The resulting predicted isoform (k) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196306, BC009047

Consensus CDS

CCDS42944.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381285.3, ENST00000398229.7

Conserved Domains (1) summary

pfam00233
Location:177 → 405

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001578.2 → NP_001001578.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks three alternate exons compared to variant 1. The resulting isoform (l) has the same N- and C-termini but lacks two internal segments compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196307, BC009047

Consensus CDS

CCDS33570.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000335365.6, ENST00000335440.10

Conserved Domains (1) summary

pfam00233
Location:209 → 437

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001579.2 → NP_001001579.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196308, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000468805.5

Conserved Domains (1) summary

pfam00233
Location:104 → 332

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001580.2 → NP_001001580.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (15) lacks six alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196309, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000460989.5

Conserved Domains (1) summary

pfam00233
Location:94 → 322

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001581.2 → NP_001001581.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks two alternate exons compared to variant 1. The resulting predicted isoform (m) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196310, BC009047

Consensus CDS

CCDS42945.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381287.3, ENST00000398232.7

Conserved Domains (1) summary

pfam00233
Location:244 → 472

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001582.2 → NP_001001582.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n

Status: REVIEWED

Description

Transcript Variant: This variant (17) lacks an alternate exon compared to variant 1. The resulting predicted isoform (n) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196311, BC009047

Consensus CDS

CCDS42942.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000381281.3, ENST00000398225.7

Conserved Domains (1) summary

pfam00233
Location:270 → 498

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001583.2 → NP_001001583.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o

Status: REVIEWED

Description

Transcript Variant: This variant (18) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (o) has the same N- and C-termini but lacks an internal segment compared to isoform a.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196312, BC009047

Consensus CDS

CCDS33569.1

UniProtKB/Swiss-Prot

O76083

Related

ENSP00000328699.6, ENST00000328862.10

Conserved Domains (1) summary

pfam00233
Location:285 → 513

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001584.3 → NP_001001584.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (19) contains an alternate exon and lacks three others compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AP001627, AY196313, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000462571.5

Conserved Domains (1) summary

pfam00233
Location:104 → 332

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001001585.2 → NP_001001585.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (20) lacks two alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, AY196314, BC009047

UniProtKB/Swiss-Prot

O76083

Related

ENST00000497805.5

Conserved Domains (1) summary

pfam00233
Location:104 → 332

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001315533.2 → NP_001302462.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p

Status: REVIEWED

Description

Transcript Variant: This variant (21) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (p) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.

Source sequence(s)

AI492065, AP001626, AP001628, AY701187

UniProtKB/Swiss-Prot

O76083

Related

ENST00000470987.5

Conserved Domains (1) summary

pfam00233
Location:203 → 431

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_002606.3 → NP_002597.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AF048837, AF067223, AI492065, AP001626, BC009047

Consensus CDS

CCDS13690.1

UniProtKB/Swiss-Prot

B2RBI5, B4DFI5, D3DSJ8, D3DSJ9, O75490, O75491, O76083, O95225, Q53Y40, Q5QD39, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0

UniProtKB/TrEMBL

A0A0S2Z4T6

Related

ENSP00000291539.6, ENST00000291539.11

Conserved Domains (1) summary

pfam00233
Location:311 → 539

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

42653621..42775509

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017028366.2 → XP_016883855.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

UniProtKB/Swiss-Prot

O76083

Conserved Domains (1) summary

pfam00233
Location:104 → 332

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_011529600.3 → XP_011527902.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

Conserved Domains (1) summary

pfam00233
Location:311 → 452

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_011529598.3 → XP_011527900.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

Conserved Domains (1) summary

pfam00233
Location:263 → 491

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

Alternate T2T-CHM13v2.0

Genomic

NC_060945.1 Alternate T2T-CHM13v2.0

Range

41042071..41163988

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054324544.1 → XP_054180519.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3
XM_054324543.1 → XP_054180518.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2
XM_054324542.1 → XP_054180517.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1
XM_054324541.1 → XP_054180516.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X4