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    Hnrnpu heterogeneous nuclear ribonucleoprotein U [ Mus musculus (house mouse) ]

    Gene ID: 51810, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hnrnpuprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Uprovided by MGI
    Primary source
    MGI:MGI:1858195
    See related
    Ensembl:ENSMUSG00000039630 AllianceGenome:MGI:1858195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAFA; Hnrpu; Sp120; hnRNP U
    Summary
    Enables RNA polymerase II C-terminal domain binding activity; nucleic acid binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including RNA localization to chromatin; cellular response to leukemia inhibitory factor; and regulation of gene expression. Acts upstream of or within with a positive effect on mRNA metabolic process. Acts upstream of or within cardiac muscle cell development and erythrocyte differentiation. Located in inactive sex chromosome and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including branchial arch; future brain; limb primordium; tail bud; and unsegmented mesenchyme. Used to study developmental and epileptic encephalopathy 54. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 88.9), CNS E14 (RPKM 47.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Hnrnpu in Genome Data Viewer
    Location:
    1 H4; 1 83.16 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178148673..178170063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178321108..178338891, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03142 Neighboring gene predicted gene, 46174 Neighboring gene STARR-seq mESC enhancer starr_03146 Neighboring gene RIKEN cDNA B230369F24 gene Neighboring gene STARR-seq mESC enhancer starr_03147 Neighboring gene STARR-seq mESC enhancer starr_03148 Neighboring gene STARR-seq mESC enhancer starr_03149 Neighboring gene cytochrome c oxidase assembly protein 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:180299062-180299171 Neighboring gene STARR-positive B cell enhancer ABC_E10066 Neighboring gene predicted gene, 24919 Neighboring gene STARR-seq mESC enhancer starr_03153 Neighboring gene EF-hand calcium binding domain 2 Neighboring gene predicted gene, 53484

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 58
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables DNA binding  
    enables RNA binding  
    enables RNA binding PubMed 
    enables RNA binding PubMed 
    enables RNA binding  
    enables RNA polymerase II C-terminal domain binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II complex binding  
    enables RNA polymerase II complex binding  
    enables TFIIH-class transcription factor complex binding  
    enables TFIIH-class transcription factor complex binding  
    enables actin binding  
    enables actin binding  
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables chromatin binding  
    enables chromatin binding  
    enables double-stranded DNA binding  
    enables double-stranded DNA binding  
    enables double-stranded RNA binding  
    enables double-stranded RNA binding  
    enables identical protein binding  
    enables identical protein binding  
    enables lncRNA binding PubMed 
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables piRNA binding  
    enables poly(A) binding  
    enables poly(A) binding  
    enables poly(C) RNA binding  
    enables poly(C) RNA binding  
    enables poly(G) binding  
    enables poly(G) binding  
    enables pre-mRNA binding  
    enables pre-mRNA binding  
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding PubMed 
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables ribonucleoprotein complex binding  
    enables ribonucleoprotein complex binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables single-stranded DNA binding  
    enables single-stranded DNA binding  
    enables single-stranded RNA binding  
    enables single-stranded RNA binding  
    enables snRNA binding  
    enables snRNA binding  
    enables telomerase RNA binding  
    enables telomerase RNA binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    Items 1 - 25 of 58
    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization  
    involved_in RNA localization to chromatin PubMed 
    involved_in RNA splicing  
    involved_in adaptive thermogenesis PubMed 
    involved_in alternative mRNA splicing, via spliceosome  
    acts_upstream_of_or_within cardiac muscle cell development PubMed 
    involved_in cell division  
    involved_in cellular response to dexamethasone stimulus  
    involved_in cellular response to glucocorticoid stimulus  
    involved_in cellular response to glucocorticoid stimulus  
    involved_in cellular response to leukemia inhibitory factor PubMed 
    involved_in circadian regulation of gene expression PubMed 
    involved_in dendritic transport of messenger ribonucleoprotein complex PubMed 
    involved_in dendritic transport of messenger ribonucleoprotein complex PubMed 
    involved_in dosage compensation by inactivation of X chromosome PubMed 
    acts_upstream_of_or_within erythrocyte differentiation PubMed 
    acts_upstream_of_or_within_positive_effect mRNA metabolic process PubMed 
    involved_in mRNA processing  
    involved_in mRNA stabilization  
    involved_in mRNA stabilization  
    involved_in maintenance of protein location in nucleus  
    involved_in maintenance of protein location in nucleus  
    involved_in negative regulation of kinase activity  
    involved_in negative regulation of kinase activity  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in negative regulation of stem cell differentiation PubMed 
    involved_in negative regulation of stem cell differentiation  
    involved_in negative regulation of telomere maintenance via telomerase  
    involved_in negative regulation of telomere maintenance via telomerase  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription elongation by RNA polymerase II  
    involved_in negative regulation of transcription elongation by RNA polymerase II  
    involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore  
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore  
    involved_in positive regulation of brown fat cell differentiation PubMed 
    involved_in positive regulation of cytoplasmic translation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of stem cell proliferation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein localization to spindle microtubule  
    involved_in protein localization to spindle microtubule  
    involved_in random inactivation of X chromosome PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome  
    involved_in regulation of alternative mRNA splicing, via spliceosome  
    involved_in regulation of chromatin organization  
    involved_in regulation of chromatin organization  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic spindle assembly  
    involved_in regulation of mitotic spindle assembly  
    involved_in regulatory ncRNA-mediated heterochromatin formation  
    Items 1 - 25 of 56
    Items 1 - 20 of 46
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex  
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in cell surface  
    located_in cell surface  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytosol  
    located_in dendrite  
    located_in inactive sex chromosome PubMed 
    located_in inactive sex chromosome  
    located_in inactive sex chromosome  
    located_in kinetochore  
    located_in kinetochore  
    located_in midbody  
    located_in midbody  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle microtubule  
    located_in mitotic spindle microtubule  
    located_in mitotic spindle midzone  
    located_in mitotic spindle midzone  
    located_in nuclear chromosome  
    located_in nuclear chromosome  
    located_in nuclear matrix  
    located_in nuclear matrix  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-containing complex  
    part_of protein-containing complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex PubMed 
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    located_in spindle pole  
    part_of telomerase holoenzyme complex  
    part_of telomerase holoenzyme complex  
    Items 1 - 20 of 46

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein U
    Names
    heterogenous nuclear ribonucleoprotein U
    nuclear matrix protein sp120
    scaffold attachment factor A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016805.3NP_058085.2  heterogeneous nuclear ribonucleoprotein U

      See identical proteins and their annotated locations for NP_058085.2

      Status: VALIDATED

      Source sequence(s)
      AC166710, AK049600, AK145499, AW123430, BY766801, CX567350
      Consensus CDS
      CCDS35804.1
      UniProtKB/Swiss-Prot
      G3XA10, Q8VEK3, Q9R205
      UniProtKB/TrEMBL
      Q3TVV6, Q3TXW2, Q3ULH5, Q8C290
      Related
      ENSMUSP00000047571.8, ENSMUST00000037748.9
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain

    RNA

    1. NR_149827.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA168064, AC166710, AK029944, AK040295, AK153188, BE650851, BY766801

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      178148673..178170063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152317.1XP_036008210.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      UniProtKB/TrEMBL
      Q3TVV6, Q3TXW2, Q3ULH5, Q8C290
      Related
      ENSMUSP00000124147.2, ENSMUST00000161769.8
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
    2. XM_036152315.1XP_036008208.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      UniProtKB/TrEMBL
      Q3TVV6, Q3TXW2, Q3ULH5, Q8C290
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
    3. XM_036152313.1XP_036008206.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      UniProtKB/TrEMBL
      Q3TVV6, Q3TXW2, Q3ULH5, Q8C290
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
    4. XM_036152312.1XP_036008205.1  heterogeneous nuclear ribonucleoprotein U isoform X1

      UniProtKB/Swiss-Prot
      G3XA10, Q8VEK3, Q9R205
      UniProtKB/TrEMBL
      Q3TVV6, Q3TXW2, Q3ULH5, Q8C290
      Conserved Domains (3) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:475619
      AAA_33; AAA domain
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