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    SPX spexin hormone [ Homo sapiens (human) ]

    Gene ID: 80763, updated on 4-Jan-2025

    Summary

    Official Symbol
    SPXprovided by HGNC
    Official Full Name
    spexin hormoneprovided by HGNC
    Primary source
    HGNC:HGNC:28139
    See related
    Ensembl:ENSG00000134548 MIM:619246; AllianceGenome:HGNC:28139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPX1; C12orf39
    Summary
    The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in fat (RPKM 72.3), thyroid (RPKM 9.5) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SPX in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (21526296..21532947)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (21405263..21411916)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21679230..21685881)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ like helicase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6090 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21654373-21655080 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21655081-21655788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6092 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:21663989-21664186 Neighboring gene golgi transport 1B Neighboring gene uncharacterized LOC124902896 Neighboring gene glycogen synthase 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:21710858-21712057 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:21748286-21748889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21810675-21811203 Neighboring gene lactate dehydrogenase B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC10946

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in dense core granule PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in transport vesicle  

    General protein information

    Preferred Names
    spexin
    Names
    NPQ
    neuropeptide Q

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030572.4NP_085049.1  spexin precursor

      See identical proteins and their annotated locations for NP_085049.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC006559, AK075342, CR742701, DA380664, DB159488
      Consensus CDS
      CCDS31757.1
      UniProtKB/Swiss-Prot
      B3KND6, Q9BT56
      Related
      ENSP00000256969.2, ENST00000256969.7
      Conserved Domains (1) summary
      pfam15171
      Location:27116
      Spexin; Neuropeptide secretory protein family, NPQ, spexin

    RNA

    1. NR_135187.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC006559, AK075342, CR742701, DA260291, DB159488
    2. NR_135188.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC006559, AK075342, CR742701, DA071522, DB159488

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      21526296..21532947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      21405263..21411916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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