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    RAB9B RAB9B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 51209, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RAB9Bprovided by HGNC
    Official Full Name
    RAB9B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:14090
    See related
    Ensembl:ENSG00000123570 MIM:300285; AllianceGenome:HGNC:14090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB9L; Rab-9L
    Summary
    This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]
    Expression
    Broad expression in heart (RPKM 9.1), brain (RPKM 5.8) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RAB9B in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103776324..103832257, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102223281..102279224, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103031252..103087187, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MORF4L2 antisense RNA 1 Neighboring gene mortality factor 4 like 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102951966-102952716 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102952717-102953467 Neighboring gene glycine receptor alpha 4 (pseudogene) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102985791-102986664 Neighboring gene transmembrane protein 31 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102996691-102997226 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102997227-102997764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103009420-103009920 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103020819-103021470 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:103022123-103022774 Neighboring gene proteolipid protein 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:103061708-103062907 Neighboring gene RNA, 5S ribosomal pseudogene 511 Neighboring gene TMSB15B antisense RNA 1 Neighboring gene H2B histone pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region. Seki N, et al. J Hum Genet, 2000. PMID 11043518
    2. Prediction of regulatory modules comprising microRNAs and target genes. Yoon S, et al. Bioinformatics, 2005 Sep 1. PMID 16204133
    3. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. Nottingham RM, et al. J Biol Chem, 2012 Jun 29. PMID 22637480, Free PMC Article
    4. Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus. Murray JL, et al. J Virol, 2005 Sep. PMID 16140752, Free PMC Article
    5. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. Espinosa EJ, et al. Cell, 2009 May 29. PMID 19490898, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
    gag Depletion of Rab9 by siRNA sequesters HIV-1 Gag within cells and causes a reduction in particle release PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-9B
    Names
    Ras-associated protein 9B
    Ras-associated protein RAB9-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016452.2 RefSeqGene

      Range
      5026..14956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016370.4 → NP_057454.1  ras-related protein Rab-9B

      See identical proteins and their annotated locations for NP_057454.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the protein.
      Source sequence(s)
      AK313425, DA501604, FO393406
      Consensus CDS
      CCDS14515.1
      UniProtKB/Swiss-Prot
      B2R8M0, Q52LX2, Q9NP90
      Related
      ENSP00000243298.2, ENST00000243298.3
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)

    RNA

    1. NR_146558.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' exon structure compared to variant 1, and is represented as non-coding because it lacks the open reading frame found in variant 1.
      Source sequence(s)
      FO393406, Z73964

    2. NR_146560.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' exon structure compared to variant 1, and is represented as non-coding because it lacks the open reading frame found in variant 1.
      Source sequence(s)
      FO393406, Z73964

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103776324..103832257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102223281..102279224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NP90.1 GenPept UniProtKB/Swiss-Prot:Q9NP90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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