U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    NXT1 nuclear transport factor 2 like export factor 1 [ Homo sapiens (human) ]

    Gene ID: 29107, updated on 10-Dec-2024

    Summary

    Official Symbol
    NXT1provided by HGNC
    Official Full Name
    nuclear transport factor 2 like export factor 1provided by HGNC
    Primary source
    HGNC:HGNC:15913
    See related
    Ensembl:ENSG00000132661 MIM:605811; AllianceGenome:HGNC:15913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P15; MTR2
    Summary
    The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.5), testis (RPKM 6.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NXT1 in Genome Data Viewer
    Location:
    20p11.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (23350791..23354771)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (23410333..23414313)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23331428..23335408)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17631 Neighboring gene long intergenic non-protein coding RNA 3125 Neighboring gene RNA, 5S ribosomal pseudogene 478 Neighboring gene Sharpr-MPRA regulatory region 4869 Neighboring gene MPRA-validated peak4168 silencer Neighboring gene Sharpr-MPRA regulatory region 11415 Neighboring gene Sharpr-MPRA regulatory region 15236 Neighboring gene uncharacterized LOC105372571 Neighboring gene NXT1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12723 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:23325274-23325494 Neighboring gene H3K27ac hESC enhancers GRCh37_chr20:23330429-23331301 and GRCh37_chr20:23331302-23332173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17637 Neighboring gene long intergenic non-protein coding RNA 1431 Neighboring gene GDNF inducible zinc finger protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (313 hits/1278 screens)

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus PubMed 
    involved_in mRNA export from nucleus  
    involved_in poly(A)+ mRNA export from nucleus  
    involved_in protein export from nucleus  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    part_of nuclear RNA export factor complex PubMed 
    part_of nuclear RNA export factor complex  
    part_of nuclear pore PubMed 
    part_of nuclear pore central transport channel  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    NTF2-related export protein 1
    Names
    NTF2-like export factor 1
    NTX2-like export factor1
    NUTF-like export factor 1
    protein p15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013248.3 → NP_037380.1  NTF2-related export protein 1

      See identical proteins and their annotated locations for NP_037380.1

      Status: REVIEWED

      Source sequence(s)
      BC003410
      Consensus CDS
      CCDS13150.1
      UniProtKB/Swiss-Prot
      Q9UKK6
      Related
      ENSP00000254998.2, ENST00000254998.3
      Conserved Domains (1) summary
      cd00780
      Location:12 → 137
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      23350791..23354771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      23410333..23414313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.