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    Camta1 calmodulin binding transcription activator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362665, updated on 27-Dec-2024

    Summary

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    Symbol
    Camta1provided by RGD
    Full Name
    calmodulin binding transcription activator 1provided by RGD
    Primary source
    RGD:1562703
    See related
    EnsemblRapid:ENSRNOG00000018602 AllianceGenome:RGD:1562703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded DNA binding activity; sequence-specific DNA binding activity; and transcription coregulator activity. Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuromuscular process controlling balance. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nonprogressive cerebellar ataxia with mental retardation. Orthologous to human CAMTA1 (calmodulin binding transcription activator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 141.2), Heart (RPKM 49.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camta1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166791639..167639502, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161510283..162356902, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168138207..169017295, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487044 Neighboring gene period circadian regulator 3 Neighboring gene vesicle-associated membrane protein 3 Neighboring gene uncharacterized LOC134487045 Neighboring gene uncharacterized LOC134487043 Neighboring gene uncharacterized LOC120103136 Neighboring gene uncharacterized LOC120103137 Neighboring gene ribosomal protein S7, pseudogene 23 Neighboring gene DnaJ heat shock protein family (Hsp40) member C11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion. Mollet IG, et al. J Biol Chem, 2016 Aug 26. PMID 27402838, Free PMC Article
    2. Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. Muller-Borer B, et al. PLoS One, 2012. PMID 22715383, Free PMC Article
    3. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Long C, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049392, Free PMC Article
    4. MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. Kang K, et al. J Biol Chem, 2013 Aug 30. PMID 23853098, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114278

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-binding transcription activator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195559.1 → NP_001182488.1  calmodulin-binding transcription activator 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC106025, JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6G9L6, A6IUF2
      Related
      ENSRNOP00000083898.1, ENSRNOT00000092887.3
      Conserved Domains (6) summary
      smart01076
      Location:67 → 183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:1075 → 1193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:881 → 960
      TIG; IPT/TIG domain
      pfam10243
      Location:1210 → 1496
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam13637
      Location:1122 → 1173
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1074 → 1117
      ANK; ANK repeat [structural motif]

    2. NM_001195560.1 → NP_001182489.1  calmodulin-binding transcription activator 1 isoform 2

      See identical proteins and their annotated locations for NP_001182489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, 3' terminal exon compared to variant 1. This results in a much shorter protein (isoform 2) that lacks the ankyrin repeats and calmodulin-binding motifs, compared to isoform 1.
      Source sequence(s)
      BC106025, BF290446, BF290447
      UniProtKB/TrEMBL
      Q3KQW8
      Related
      ENSRNOP00000063320.3, ENSRNOT00000067481.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166791639..167639502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288086.1 → XP_063144156.1  calmodulin-binding transcription activator 1 isoform X2

      UniProtKB/TrEMBL
      A6IUF2

    2. XM_063288088.1 → XP_063144158.1  calmodulin-binding transcription activator 1 isoform X6

      UniProtKB/TrEMBL
      A6IUF2

    3. XM_039110445.2 → XP_038966373.1  calmodulin-binding transcription activator 1 isoform X5

      UniProtKB/TrEMBL
      A6IUF2
      Conserved Domains (4) summary
      smart01076
      Location:67 → 183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:1074 → 1117
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:881 → 960
      TIG; IPT/TIG domain
      pfam12796
      Location:1079 → 1171
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039110444.2 → XP_038966372.1  calmodulin-binding transcription activator 1 isoform X4

      UniProtKB/TrEMBL
      A6IUF2
      Related
      ENSRNOP00000103181.1, ENSRNOT00000171771.1
      Conserved Domains (4) summary
      smart01076
      Location:67 → 183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:1074 → 1117
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:881 → 960
      TIG; IPT/TIG domain
      pfam12796
      Location:1079 → 1171
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_039110438.2 → XP_038966366.1  calmodulin-binding transcription activator 1 isoform X3

      UniProtKB/TrEMBL
      A6IUF2
      Conserved Domains (4) summary
      smart01076
      Location:67 → 183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:1074 → 1117
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:881 → 960
      TIG; IPT/TIG domain
      pfam12796
      Location:1079 → 1171
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_039110436.2 → XP_038966364.1  calmodulin-binding transcription activator 1 isoform X1

      UniProtKB/TrEMBL
      A6IUF2
      Related
      ENSRNOP00000059056.5, ENSRNOT00000066120.5
      Conserved Domains (4) summary
      smart01076
      Location:67 → 183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:1074 → 1117
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:881 → 960
      TIG; IPT/TIG domain
      pfam12796
      Location:1079 → 1171
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_063288090.1 → XP_063144160.1  calmodulin-binding transcription activator 1 isoform X8

      UniProtKB/TrEMBL
      F1M4M6

    8. XM_063288089.1 → XP_063144159.1  calmodulin-binding transcription activator 1 isoform X7

    9. XM_063288092.1 → XP_063144162.1  calmodulin-binding transcription activator 1 isoform X10

    10. XM_063288091.1 → XP_063144161.1  calmodulin-binding transcription activator 1 isoform X9

    RNA

    1. XR_010066428.1 RNA Sequence

    2. XR_010066435.1 RNA Sequence

    3. XR_010066434.1 RNA Sequence

    4. XR_010066427.1 RNA Sequence

    5. XR_010066426.1 RNA Sequence

    6. XR_010066429.1 RNA Sequence

    7. XR_010066430.1 RNA Sequence

    8. XR_010066432.1 RNA Sequence

    9. XR_010066431.1 RNA Sequence

    10. XR_010066433.1 RNA Sequence

    11. XR_010066436.1 RNA Sequence

    12. XR_010066439.1 RNA Sequence

    13. XR_010066440.1 RNA Sequence

    14. XR_010066437.1 RNA Sequence

    15. XR_010066438.1 RNA Sequence

    16. XR_005504502.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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