Peli1 pellino E3 ubiquitin protein ligase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Peli1provided by RGD
Official Full Name: pellino E3 ubiquitin protein ligase 1provided by RGD
Primary source: RGD:1311199
See related: EnsemblRapid:ENSRNOG00000006329 AllianceGenome:RGD:1311199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in several processes, including negative regulation of TORC1 signaling; negative regulation of necroptotic process; and positive regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within several processes, including positive regulation of signal transduction; regulation of lymphocyte proliferation; and regulation of macromolecule metabolic process. Predicted to be located in nucleus. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PELI1 (pellino E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 175.7), Lung (RPKM 167.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (99455970..99510474)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (95254274..95309168)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (106008086..106062566)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The involvement of Pellino-1 downregulation in the modulation of visceral hypersensitivity via the TLR4/NF-kappaB pathway in the rat fastigial nucleus.
Title: The involvement of Pellino-1 downregulation in the modulation of visceral hypersensitivity via the TLR4/NF-κB pathway in the rat fastigial nucleus.
Pellino1 deficiency reprograms cardiomyocytes energy metabolism in lipopolysaccharide-induced myocardial dysfunction.
Title: Pellino1 deficiency reprograms cardiomyocytes energy metabolism in lipopolysaccharide-induced myocardial dysfunction.
Pellino1 silencing prevented the binding of NF-kappaB and AP-1 to the promoter region of transforming growth factor-beta1 (TGF-beta1) thus dampening TGF-beta1 transactivation.
Title: Pellino1-mediated TGF-β1 synthesis contributes to mechanical stress induced cardiac fibroblast activation.

Submit: New GeneRIF Correction

General gene information

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Markers

BQ194767 (e-PCR)
- UniSTS:261895

UniSTS:226084 (e-PCR)
- UniSTS:226084

Peli1 (e-PCR), detects polymorphism
- UniSTS:226084

D11Ertd676e (e-PCR), detects polymorphism
- UniSTS:167069

RH141447 (e-PCR)
- UniSTS:223441

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of Toll signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase pellino homolog 1

Names: pellino 1; pellino homolog 1

NP_001094035.1

EC 2.3.2.27

XP_063129309.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.