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    St6galnac4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407764, updated on 27-Dec-2024

    Summary

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    Official Symbol
    St6galnac4provided by RGD
    Official Full Name
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4provided by RGD
    Primary source
    RGD:1303005
    See related
    AllianceGenome:RGD:1303005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    siat7D
    Summary
    Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process and oligosaccharide metabolic process. Predicted to be located in Golgi membrane. Orthologous to human ST6GALNAC4 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 104.7), Kidney (RPKM 92.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St6galnac4 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36269834..36282971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15872230..15885250)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11607103..11619595)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene adenylate kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
    Names
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
    ST6 GalNAc alpha-2,6-sialyltransferase 4
    alpha-2,6-sialyltransferase ST6GalNAc IV
    NP_001386308.1
    NP_001386309.1
    XP_008760009.4
    XP_017447604.3
    XP_038962109.2
    XP_063140383.1
    XP_063140384.1
    XP_063140385.1
    XP_063140386.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399379.1 → NP_001386308.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8J8XJY2, M0R8B3, Q6ZXZ0
      Conserved Domains (1) summary
      pfam00777
      Location:56 → 289
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001399380.1 → NP_001386309.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8J8XJY2, M0R8B3, Q6ZXZ0
      Conserved Domains (1) summary
      pfam00777
      Location:56 → 289
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36269834..36282971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284316.1 → XP_063140386.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X5

    2. XM_039106181.2 → XP_038962109.2  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X2

    3. XM_063284315.1 → XP_063140385.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X4

    4. XM_017592115.3 → XP_017447604.3  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8J8XJY2, M0R8B3, Q6ZXZ0

    5. XM_063284313.1 → XP_063140383.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X3

    6. XM_008761787.4 → XP_008760009.4  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X2

    7. XM_063284314.1 → XP_063140384.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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