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    Cep170 centrosomal protein 170 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171457, updated on 27-Dec-2024

    Summary

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    Symbol
    Cep170provided by RGD
    Full Name
    centrosomal protein 170provided by RGD
    Primary source
    RGD:621868
    See related
    EnsemblRapid:ENSRNOG00000004127 AllianceGenome:RGD:621868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kab; KAB1; Rhk1
    Summary
    Predicted to be located in centrosome and cytosol. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centriole. Orthologous to human CEP170 (centrosomal protein 170). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 252.9), Thymus (RPKM 183.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep170 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (91201808..91285990, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (88669672..88754011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (94807090..94887448, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene beclin 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phospholipase D family, member 5 Neighboring gene microRNA 350 Neighboring gene SHH signaling and ciliogenesis regulator SDCCAG8 Neighboring gene uncharacterized LOC134481601 Neighboring gene AKT serine/threonine kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death. Do E, et al. Mol Cell Biochem, 2003 Jun. PMID 12870657
    2. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. Kodani A, et al. EMBO J, 2013 Feb 20. PMID 23386061, Free PMC Article
    3. 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Sonnen KF, et al. Biol Open, 2012 Oct 15. PMID 23213374, Free PMC Article
    4. A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Nechipurenko IV, et al. Dev Cell, 2016 Sep 12. PMID 27623382, Free PMC Article
    5. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular cloning; localized in cell nucleus and in the condensed chromosome during the mitotic cell division; works as a protective protein against cell damage by oxidative stress
      Title: Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 170 kDa
    Names
    KARP-1 binding protein 1
    centrosomal protein 170kDa
    centrosomal protein of 170 kDa-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427216.1 → NP_001414145.1  centrosomal protein of 170 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGC3
      Related
      ENSRNOP00000005532.6, ENSRNOT00000005532.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      91201808..91285990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272008.1 → XP_063128078.1  centrosomal protein of 170 kDa isoform X16

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    2. XM_063272007.1 → XP_063128077.1  centrosomal protein of 170 kDa isoform X15

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    3. XM_063272006.1 → XP_063128076.1  centrosomal protein of 170 kDa isoform X14

      UniProtKB/TrEMBL
      A6JGC3

    4. XM_063272005.1 → XP_063128075.1  centrosomal protein of 170 kDa isoform X13

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    5. XM_063272004.1 → XP_063128074.1  centrosomal protein of 170 kDa isoform X12

      UniProtKB/TrEMBL
      A6JGC3

    6. XM_063272003.1 → XP_063128073.1  centrosomal protein of 170 kDa isoform X11

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    7. XM_063272002.1 → XP_063128072.1  centrosomal protein of 170 kDa isoform X10

      UniProtKB/TrEMBL
      A6JGC3

    8. XM_063272000.1 → XP_063128070.1  centrosomal protein of 170 kDa isoform X8

      UniProtKB/TrEMBL
      A6JGC3

    9. XM_063271999.1 → XP_063128069.1  centrosomal protein of 170 kDa isoform X7

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5, D3ZET9, F1LNI7

    10. XM_063272001.1 → XP_063128071.1  centrosomal protein of 170 kDa isoform X9

      UniProtKB/TrEMBL
      A6JGC3

    11. XM_063271998.1 → XP_063128068.1  centrosomal protein of 170 kDa isoform X6

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    12. XM_063271997.1 → XP_063128067.1  centrosomal protein of 170 kDa isoform X5

      UniProtKB/TrEMBL
      A6JGC3

    13. XM_063271996.1 → XP_063128066.1  centrosomal protein of 170 kDa isoform X4

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    14. XM_063271995.1 → XP_063128065.1  centrosomal protein of 170 kDa isoform X3

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    15. XM_063271994.1 → XP_063128064.1  centrosomal protein of 170 kDa isoform X2

      UniProtKB/TrEMBL
      A6JGC3

    16. XM_063271993.1 → XP_063128063.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5
      Related
      ENSRNOP00000072465.3, ENSRNOT00000079763.3

    17. XM_063272009.1 → XP_063128079.1  centrosomal protein of 170 kDa isoform X17

      UniProtKB/TrEMBL
      A0A0G2K315, A6JGC5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134416.1: Suppressed sequence

      Description
      NM_134416.1: This RefSeq was temporarily suppressed because there were several mismatches, insertions, and deletions compared to available sequence data. These differences resulted in a protein that was truncated at both ends and
    Nucleotide Protein Strain
    Heading Accession and Version

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