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    Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361802, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Hsd17b8provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 8provided by RGD
    Primary source
    RGD:1303158
    See related
    EnsemblRapid:ENSRNOG00000000466 AllianceGenome:RGD:1303158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ke6; Fabgl; RING2
    Summary
    Predicted to enable several functions, including (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity; NADH binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and protein heterotetramerization. Predicted to act upstream of or within androgen metabolic process and estrogen metabolic process. Predicted to be located in mitochondrial envelope; mitochondrial matrix; and plasma membrane. Predicted to be part of oxidoreductase complex. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 229.9), Kidney (RPKM 172.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsd17b8 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4828571..4830635)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4826725..4828742)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3817212..3819316, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene collagen type XI alpha 2 chain Neighboring gene retinoid X receptor beta Neighboring gene solute carrier family 39 member 7 Neighboring gene microRNA 219a-1 Neighboring gene ring finger protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. Ohno S, et al. Mol Cell Biochem, 2008 Feb. PMID 17978863
    2. Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. Fomitcheva J, et al. J Biol Chem, 1998 Aug 28. PMID 9712896
    3. 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. Chen Z, et al. FASEB J, 2009 Nov. PMID 19571038
    4. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Venkatesan R, et al. Nat Commun, 2014 Sep 9. PMID 25203508
    5. Aberrant 11beta-hydroxysteroid dehydrogenase-1 activity in the cpk mouse: implications for regulation by the Ke 6 gene. Aziz N, et al. Endocrinology, 1996 Dec. PMID 8940387

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109594

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of oxidoreductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxidoreductase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    (3R)-3-hydroxyacyl-CoA dehydrogenase
    Names
    17-beta-HSD 8
    17-beta-hydroxysteroid dehydrogenase 8
    3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit
    3-oxoacyl-[acyl-carrier-protein] reductase
    KAR alpha subunit
    estradiol 17-beta-dehydrogenase 8
    testosterone 17-beta-dehydrogenase 8
    NP_997694.1
    XP_006256026.1
    XP_006256027.1
    XP_006256028.1
    XP_038954738.1
    XP_063135282.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212529.1 → NP_997694.1  (3R)-3-hydroxyacyl-CoA dehydrogenase

      See identical proteins and their annotated locations for NP_997694.1

      Status: VALIDATED

      Source sequence(s)
      BX883042
      UniProtKB/Swiss-Prot
      Q6MGB5
      UniProtKB/TrEMBL
      A6JJG1
      Related
      ENSRNOP00000073887.3, ENSRNOT00000081486.4
      Conserved Domains (1) summary
      cd05333
      Location:11 → 258
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4828571..4830635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098810.2 → XP_038954738.1  (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X4

      Conserved Domains (1) summary
      cl21454
      Location:16 → 218
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_006255964.5 → XP_006256026.1  (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6P1
      Related
      ENSRNOP00000098200.1, ENSRNOT00000120559.2
      Conserved Domains (1) summary
      cd05333
      Location:16 → 257
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    3. XM_006255966.5 → XP_006256028.1  (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A0G2K156
      Conserved Domains (1) summary
      cd05333
      Location:16 → 260
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    4. XM_006255965.5 → XP_006256027.1  (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X2

      See identical proteins and their annotated locations for XP_006256027.1

      UniProtKB/TrEMBL
      A6JJG3
      Related
      ENSRNOP00000101602.1, ENSRNOT00000131886.1
      Conserved Domains (1) summary
      cd05333
      Location:11 → 255
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    5. XM_063279212.1 → XP_063135282.1  (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X5

    RNA

    1. XR_362002.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MGB5.1 GenPept UniProtKB/Swiss-Prot:Q6MGB5

    Gene LinkOut

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