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    Panx1 Pannexin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315435, updated on 4-Jan-2025

    Summary

    Official Symbol
    Panx1provided by RGD
    Official Full Name
    Pannexin 1provided by RGD
    Primary source
    RGD:735204
    See related
    EnsemblRapid:ENSRNOG00000010060 AllianceGenome:RGD:735204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    px1
    Summary
    The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms could attenuate the actions of the membrane-bound protein. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Brain (RPKM 30.6), Thymus (RPKM 24.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Panx1 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (20128783..20171200, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (11851176..11889774, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (13567185..13606040, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479994 Neighboring gene dipeptidylpeptidase 3, pseudogene 1 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene hephaestin-like 1 Neighboring gene ribosomal protein S24, pseudogene 16 Neighboring gene 40S ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP transmembrane transporter activity  
    enables ATP transmembrane transporter activity  
    enables actin binding  
    enables actin filament binding  
    enables calcium channel activity  
    enables calcium channel activity  
    enables channel activity  
    enables gap junction channel activity PubMed 
    NOT enables gap junction hemi-channel activity PubMed 
    enables identical protein binding  
    enables leak channel activity  
    enables leak channel activity  
    enables monoatomic anion channel activity  
    enables monoatomic anion channel activity  
    enables protease binding PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables scaffold protein binding PubMed 
    enables signaling receptor binding  
    enables structural molecule activity PubMed 
    enables transmembrane transporter binding PubMed 
    enables wide pore channel activity  
    Process Evidence Code Pubs
    involved_in ATP transport  
    involved_in ATP transport  
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport  
    involved_in calcium ion transport  
    involved_in cell-cell signaling  
    involved_in cell-cell signaling PubMed 
    involved_in monoatomic anion transmembrane transport  
    involved_in monoatomic anion transmembrane transport  
    involved_in monoatomic cation transport  
    involved_in monoatomic cation transport  
    involved_in monoatomic cation transport  
    acts_upstream_of_or_within positive regulation of interleukin-1 alpha production  
    acts_upstream_of_or_within positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 production  
    acts_upstream_of_or_within positive regulation of macrophage cytokine production  
    acts_upstream_of_or_within response to ATP  
    acts_upstream_of_or_within response to ischemia  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in bleb  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in gap junction  
    located_in gap junction  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of protein-containing complex PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270548.1NP_001257477.1  pannexin-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon and lacks the following alternate exon compared to variant 1. The resulting isoform (c) has a short alternate aa sequence in place of a larger segment compared to isoform a.
      Source sequence(s)
      BM385439, GQ499839, GQ499840, JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2KA39, E0X642
      Related
      ENSRNOP00000075246.1, ENSRNOT00000083395.3
    2. NM_001270549.1NP_001257478.1  pannexin-1 isoform d

      See identical proteins and their annotated locations for NP_001257478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BM385439, GQ499839, GQ499840, JAXUCZ010000008
      UniProtKB/TrEMBL
      E0X643
    3. NM_199397.2NP_955429.1  pannexin-1 isoform a

      See identical proteins and their annotated locations for NP_955429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BM385439, JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P60570
      UniProtKB/TrEMBL
      A6JNB1, E0X642
      Related
      ENSRNOP00000013577.3, ENSRNOT00000013577.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      20128783..20171200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081351.2XP_038937279.1  pannexin-1 isoform X1

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