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    Pds5a PDS5 cohesin associated factor A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pds5aprovided by RGD
    Official Full Name
    PDS5 cohesin associated factor Aprovided by RGD
    Primary source
    RGD:1307094
    See related
    EnsemblRapid:ENSRNOG00000002541 AllianceGenome:RGD:1307094
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scc-112; RGD1307094
    Summary
    Predicted to be involved in DNA repair; mitotic sister chromatid cohesion; and negative regulation of DNA replication. Predicted to act upstream of or within several processes, including lens development in camera-type eye; neuroblast migration; and roof of mouth development. Predicted to be located in chromatin; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 354.9), Spleen (RPKM 270.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pds5a in Genome Data Viewer
    Location:
    14p11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42905734..43004740)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42551653..42651074)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44185445..44282308)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 8, pseudogene 3 Neighboring gene NEDD4 binding protein 2 Neighboring gene ras homolog family member H Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14 like 2 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors. Hagemann C, et al. Int J Mol Med, 2011 Jan. PMID 21069257
    2. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. Zhang B, et al. PLoS One, 2009. PMID 19412548, Free PMC Article
    3. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
    4. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
    5. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Nishiyama T, et al. Cell, 2010 Nov 24. PMID 21111234

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.
      Title: The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neuroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sister chromatid cohesion protein PDS5 homolog A
    Names
    PDS5, regulator of cohesion maintenance, homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083624.1 → NP_001077093.1  sister chromatid cohesion protein PDS5 homolog A

      See identical proteins and their annotated locations for NP_001077093.1

      Status: PROVISIONAL

      Source sequence(s)
      EF460313
      UniProtKB/Swiss-Prot
      A4L9P7
      Related
      ENSRNOP00000003437.7, ENSRNOT00000003437.8
      Conserved Domains (2) summary
      sd00044
      Location:282 → 312
      HEAT; HEAT repeat [structural motif]
      cd19953
      Location:40 → 670
      PDS5; Sister chromatid cohesion protein PDS5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      42905734..43004740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091918.2 → XP_038947846.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q0A3, A6JDD2
      Related
      ENSRNOP00000107870.1, ENSRNOT00000143027.1
      Conserved Domains (2) summary
      sd00044
      Location:282 → 312
      HEAT; HEAT repeat [structural motif]
      cd19953
      Location:40 → 670
      PDS5; Sister chromatid cohesion protein PDS5

    2. XM_063273132.1 → XP_063129202.1  sister chromatid cohesion protein PDS5 homolog A isoform X3

    3. XM_063273131.1 → XP_063129201.1  sister chromatid cohesion protein PDS5 homolog A isoform X2

      UniProtKB/Swiss-Prot
      A4L9P7

    4. XM_063273133.1 → XP_063129203.1  sister chromatid cohesion protein PDS5 homolog A isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4L9P7.1 GenPept UniProtKB/Swiss-Prot:A4L9P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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